... to mitigate axon degeneration in injury and disease. axon injury Wallerian degeneration SARM1 USP13 deubiquitination In neural injury, the distal segment of an injured nerve undergoes the characteristic morphological changes, including axon beading, fragmentation, self-destruction, and engulfment...

... evident in tauopathy bear striking morphological resemblance to those reported in models of Wallerian degeneration. The mechanisms underpinning Wallerian degeneration are not fully understood although it can be delayed by the expression of the slow Wallerian degeneration (Wld^S) protein, which...

... itself, a commonly held view is that this association is driven by Wallerian degeneration of descending fibres, a process that describes how axons passing through the lesion degenerate over time. ⁷ However, several methodological limitations hinder a confirmation of this notion...

... expression profiles of resident macrophages in peripheral nerves and described differential activation of macrophage subsets during and after acute sciatic nerve injury. endoneurial perineurial sciatic nerve Wallerian degeneration The macrophages of the PNS have been described as a local surveillance...

.... Axon degeneration is seen consistently after traumatic brain injury (TBI). Henninger et al. show that mice lacking the kinase scaffold Sarm1, a mediator of Wallerian degeneration, display substantially attenuated axon degeneration and reduced functional deficits in a closed-head TBI model...

... Wallerian degeneration Wld^s The olfactory receptor neuron (ORN) model was the first system developed to study axotomy in Drosophila ( MacDonald et al. 2006 ). ORNs are the chemosensory neurons found in the adult third antennal segment or maxillary palps, which send axonal projections...

... < HD higher scores mean greater impairment. b Pre-HD CTL < HD CTL. c Pre-HD > HD higher scores mean lesser impairment. axonal demyelination diffusion tensor imaging region of interest voxel-based morphometry Wallerian degeneration white matter changes Huntington's disease (HD...

...Yuk Shan Chen; Stephen S. Chung; Sookja K. Chung Aldose reductase Diabetes Nerve regeneration thy1-YFP mice Wallerian degeneration Diabetic neuropathy is the most common and debilitating complication of diabetic mellitus, causing greater morbidity and mortality than other diabetic...

...:https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Abstract A chimeric protein called Wallerian degeneration slow (Wld^S) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool...

... section of all rami communicantes of the sympathetic ganglia. The histological regeneration might be greater than the recurrence rates of clinical symptoms seen in a human being due to non-functional regenerations. Sympathectomy Video-assisted thoracic surgery Wallerian degeneration Schwann cells...

... around blood vessels and then progressively spread to the parenchyma. In the distal segments, where Wallerian degeneration has occurred, the corresponding process is relatively slow and the phagocytes originate intrinsically. In contrast, these phagocytes are first seen in the parenchyma and then later...

... undergoing Wallerian degeneration and of an extension of the cervical lesion into the high thoracic cord. CONCLUSION: MRI, the only imaging technique that currently provides useful information on the spinal cord parenchyma after trauma, is rapidly evolving. High-field scanners of up to 9.4 T are being...

[email protected] 2005 Abstract Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. This process of degeneration, which requires an effective macrophage response, occurs rapidly in peripheral nerves but is slow...

... Wallerian degeneration gene, Wld^S, delays Wallerian degeneration after injury, and also delays ‘dying-back’ in peripheral nervous system disorders, revealing a mechanistic link between two forms of axon degeneration traditionally considered distinct. We now report...

...A. Buss; K. Pech; D. Merkler; B. A. Kakulas; D. Martin; J. Schoenen; J. Noth; M. E. Schwab; G. A. Brook Brain Vol. 128 No. 2 © Guarantors of Brain 2005; all rights reserved 2005 Abstract Axons undergo Wallerian degeneration (WD) distal to a point of injury. In the lesioned PNS, WD may...

... into three groups according to the post‐injury survival times (early, intermediate and late survival times), because distinct morphological stages in the course of Wallerian degeneration and the astrocytic reaction were found. A number of CNS myelin‐associated proteins have been identified that contribute...

... and are consistent with the hypothesis that lysophosphatidic acid promotes in vivo Schwann cell mitogenesis in regenerating peripheral nerve. EDG receptor G-protein coupled receptor Schwann cell Sphingosine-1-phosphate Wallerian degeneration Despite its clear importance to successful regeneration in injured...

... Association of Neuropathologists 2001 Abstract Wallerian degeneration is characterized by breakdown of myelin and axons with subsequent macrophage infiltration and removal of the degenerating nerve components. Proteinases of the matrix metalloproteinase (MMP) family seem to play an important role...

... Lipoproteins Macrophages Myelination Niemann-Pick C disease Peripheral nerve Wallerian degeneration. A semiautomated method for quantification of myelinated fiber data was performed as described by Rath et al ( 20 ). All nerves were sampled 2–3 mm from the site of crush. Video images of cross sections...

... to be Wallerian degeneration of the axons transected in multiple sclerosis lesions, but the possibility of a more generalized axonopathy could not be discounted. To investigate this hypothesis, we extended our pathological studies in order to examine the relationship between the regional multiple sclerosis lesion...