..., provided the original work is properly cited. See the journal About page for additional terms. Abstract Objective To evaluate the efficacy and safety in adolescent boys with idiopathic short stature (ISS) when treated with third-generation aromatase inhibitors (AIs), the combination of letrozole...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Context Short-statured midpubertal boys with predicted adult height (PAHt) below the third percentile are a therapeutic challenge...

... well characterized in youth. Objective To investigate the impact of GH on skeletal muscle in boys with significant short stature (SS) compared with age-matched, normally growing controls. Methods This was an open-label comparator at an outpatient endocrine clinic. Participants were 45...

... hypogonadism tall stature obesity Barts Charity 10.13039/100015652 Central hypothyroidism (CeH) is a disorder of low free serum thyroxine caused by a lack of stimulation of a normal thyroid gland, either due to pituitary (secondary hypothyroidism) or hypothalamic dysfunction (tertiary hypothyroidism) [ 1...

... of GHSR haploinsufficiency and its growth response to GH treatment. Methods This case series includes 26 patients with short stature and heterozygous GHSR variants. Pathogenicity was studied in vitro using total protein levels, cell surface expression, and receptor activity in basal...

... are associated with hypocalcemia and normal or inappropriately low levels of circulating PTH. ADH1 patients typically manifest hypercalciuria, while ADH2 is associated with short stature in approximately 42% of cases. We evaluated a 10-yr-old boy with hypoparathyroidism and short stature. Biochemical analyses...

... of Egyptian children (in El Minya Government Primary School) with normal healthy and correlate it with short stature. Methods This is A Cross section simple randomization study for 6month from December 2022 to May 2023 At Elemam malk and Elweahada primary schools at Nazlet Elbarsha village on El Minia...

.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms. Abstract Context Patients with aggrecan (ACAN) deficiency present with dominantly inherited short stature, as well as early...

...Antoinette Farrell; Sunitha R Sura Figure 1. Centers for Disease Control and Prevention’s boys growth chart: height and weight. Abstract Despite tall stature being a characteristic feature of Klinefelter syndrome, occasional cases of short stature have been reported. These cases are often...

...Berenice B Mendonca; Ivo J P Arnhold A frequent complaint of short stature occurs at the time of normal puberty, primarily seen in males. An otherwise healthy child growing in the lower normal range who has a delay in the onset of puberty, and consequent delay of his or her pubertal growth spurt...

... not present with the classical BDA1 phenotype but with a more variable phenotype: With/without short stature and/or mild brachydactyly. ^{27 , 28} Interestingly, approximately half of these variants are located in the IHH-C peptide. The absence of functional studies beyond the first IHH...

..., referral, investigation, and diagnosis of children with growth disorders . Horm Res Paediatr 2016 ; 85 ( 5 ): 325 – 32 . doi: 10.1159/000444525 2. Grote FK , van Dommelen P , Oostdijk W , et al. Developing evidence-based guidelines for referral for short stature . Arch Dis...

... percentile; 0.6 SDS). At the time of referral, he had shown persistent severe failure to thrive. There were no concerns about his hearing, vision, or social development. The patient had profound short stature, macrocephaly (head circumference 47 cm; −0.3 SDS) with a prominent occiput and a degree of frontal...

... growth outcomes were defined according to the following definitions in each NHSPIC round: (1) short stature, HT for age at Z-score (HAZ) less than −2 SDS; (2) underweight, WT for age at Z-score (WAZ) less than −2 SDS; (3) microcephaly, HC for age at Z-score less than −2 SDS...

...Anna Bogusławska; Magdalena Godlewska; Alicja Hubalewska-Dydejczyk; Márta Korbonits; Jerzy Starzyk; Aleksandra Gilis-Januszewska Height is variable in the population and is influenced both by genetics (∼80%) and by environmental factors (∼20%). ^16-20 Tall stature (TS) is usually...

... stature syndromic tall stature non-syndromic tall stature next-generation sequencing Ministry of Health of the Czech Republic 10.13039/501100003243 NU21-07-00335 Tall stature (TS) is not considered as a pathological condition by itself, but numerous disorders may cause excessive growth ( 1 ). When...

... is properly cited. For commercial re-use, please contact [email protected] Abstract Objective SOFT syndrome (MIM#614813), denoting Short stature, Onychodysplasia, Facial dysmorphism, and hypoTrichosis, is a rare primordial dwarfism syndrome caused by biallelic variants in POC1A...

... endocrine-related etiologies of short stature amenable to hormonal treatment, defects in the growth hormone (GH)–insulin-like growth factor I axis remain pre-eminent, with a multiplicity of disorders causing decreased secretion or insensitivity to GH action. Sex steroids in puberty increase epiphyseal...

... short stature adrenal The management of classic congenital adrenal hyperplasia (CAH) in pediatric patients entails the intricate balance of replacing sufficient glucocorticoids to treat adrenal insufficiency and suppress excess adrenal androgen production while maintaining normal growth. Patients...

..., certain subgroups may be at elevated risk of suicide. Studies are needed to better understand the nature and magnitude of suicide risk among c-hGH recipients to facilitate early intervention to prevent suicide deaths. human growth hormone pituitary growth hormone suicide US cohort study short stature...