... the external granular layer (EGL) and Purkinje cell plate (PCP) with the support of radial glial cells. By ED 25, the cerebellar cortex had developed three distinct layers: the EGL, PCP, and the prospective molecular layer (PML), with radial glial cells localized in the PCP. Differentiation continued, and upon...

... of low mood and aversion to activity. Here we studied the effect of long-term injections of SK channels activator chlorzoxazone (CHZ) together and separately with the folic acid (FA) on the cerebellar Purkinje cell (PC) firing and histology, and also on the motor and cognitive functions as well as mood...

... several decades for research into brain mechanisms to become established. Both neuropathological and imaging studies found differences in the cerebellum in autism spectrum disorder, the most widely documented being a decreased density of Purkinje cells in the cerebellar cortex. The popular interpretation...

... of the e parameter, by an increasing Hill function ( Fig. 2 ). Fig. 2 Mathematical modeling of Purkinje cell dynamics. The differential equation yielding the variation along time of the left flocculonodular Purkinje cell firing rate, represented by P_L, contains an increasing Hill...

..., the corpus cerebelli, and the vestibulolateral lobe. Characteristically, the cerebellar cortex contained three well-distinct layers: an outer molecular, intermediate ganglionic, and inner granular layer. The ganglionic layer possessed irregularly arranged Purkinje cells and eurydendroid cells that extended...

... a range of structural changes in the ET cerebellar cortex compared to that of controls. These changes, which are centered on the Purkinje cell (PC) and neighboring neuronal populations, include an increase in the number of torpedoes and related PC axonal changes, an increase in number of PC dendritic...

... neuropathology of two patients with SCA37 revealed severe loss of Purkinje cells with abundant astrogliosis, empty baskets, occasional axonal spheroids, and hypertrophic fibres by phosphorylated neurofilament immunostaining in the cerebellar cortex. The remaining cerebellar Purkinje neurons showed loss...

.../30). Data are expressed as mean of 5 trials±SEM, 2-way ANOVA followed by Tukey’s posthoc were performed (*P<.05, **P<.01, ***P<.001). Figure 5. Loss of neurons in mice prenatally exposed to VPA is sex and region specific. (A–F) Stereological Purkinje cell (PC...

... from the primary (M1) or secondary (M2) motor cortices, or the primary somatosensory cortex (S1) to zebrin-identified Purkinje cells of the cerebellar cortex. Our results indicate not only that projections from multiple zones converge onto a single functional domain of the cortex but also...

..., or malignancies of neuroectodermal origin, such as small cell lung cancer, as such treatment may promote paraneoplastic neurologic disorders. paraneoplastic neurological disorder CTLA4 immunotherapy Purkinje cells neuroinflammation Paraneoplastic neurological disorders are immune-mediated diseases...

... circadian rhythmicity on metabolic health. bioluminescence circadian homeostasis clock genes cerebral cortex hippocampus cerebellum Purkinje cells The timing and quality of both sleep and wakefulness depend on the interaction of two processes. A sleep-wake-driven process monitors and controls...

..., and intracardiac electrical recordings from patients with heritable and acquired forms of heart disease suggest that Purkinje cells (PCs) may also serve as critical triggers of life-threatening arrhythmias. Nonetheless, owing to the difficulty in isolating and studying this rare population of cells, the precise...

... subjects, but mean total Purkinje cell numbers in SIDS versus controls was recently found not to be different. Probably the best marker for chronic hypoxia in a brain region is the microvessel length per unit volume of tissue, that is, the microvessel length density (MLD). Here, we investigated MLDs using...

... endogenous and therapeutic central nervous system repair is how damaged (or senescent) neurons, given their often enormously complex and extensive network of connections, can possibly be replaced. The recent observation of fusion of circulating bone marrow cells with, in particular, cerebellar Purkinje cells...

... with the p38MAPK inhibitor SB203580, starting at 1 month old, Atm^−/− mice showed restoration of normal levels of Bmi-1 and p21 with the rescue of NSC population in the SVZ. In addition, treated Atm^−/− mice exhibited more Purkinje cells in the cerebellum. Most importantly...

... with cytoplasmic proteins of cerebellar Purkinje cells. Because these antibodies interact with cytoplasmic rather than cell surface membrane proteins, their role in causing Purkinje cell death has been questioned. To address this issue, we studied the interaction of anti-Yo antibodies with Purkinje cells in slice...

... numbers of torpedoes and Purkinje cell (PC) loss have been documented in the brains of patients with ET. We recently observed a dense and tangled appearance ("hairiness") of the basket cell axonal plexuses that surround PC soma in Bielschowsky preparations of cerebellar cortex in ET brains. Here, we...

...Joshua D. Bell; Jinglu Ai; Yonghong Chen; Andrew J. Baker GluR2 AMPA stretch traumatic brain injury cerebellum Purkinje cells calcium endocytosis In supporting our hypothesis, recent work from Liu et al. ( 2006 ) suggests that mild in vitro ischaemia can alter GluR2...

... showed high signal intensity in the cerebral peduncles. The main neuropathology in the 3 cases was severe diffuse loss of Purkinje cells associated with heat shock protein 70 expression by Bergmann glia. In situ end labeling was negative in surviving Purkinje cells, suggesting that the mechanism...

..., neuromuscular dysfunction begins at 5 weeks and death occurs at 13 weeks of age. Cholesterol accumulates in every tissue in the body. Purkinje cell loss in the cerebellum begins at 3 to 4 weeks of age and is nearly complete by 11 weeks. This neurodegeneration in the cerebellum is associated with increases...