... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is a condition that was only identified relatively recently. It often presents...

... the underlying disease mechanisms, and enables testing of new treatments over an extended disease course. NMDA receptor encephalitis active immunization SGE-301 immunotherapy animal model treatments Determination of the presence of IgG in brain, immunoprecipitation of IgG bound to NMDAR, and assessment...

... pleocytosis (white blood cell count of more than five cells per mm³)   • MRI features suggestive of encephalitis  3. Reasonable exclusion of alternative causes Graus criteria for probable NMDA receptor encephalitis ⁴⁴ Diagnosis can be made when all three...

... SVM patterns of structural alterations anti-NMDA receptor encephalitis Corresponding authors: Jinmei Li, Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China. Email: [email protected] ; Zhuoling Xiao, School of Information and Communication Engineering...

... thymectomy for anti-NMDA receptor encephalitis is needed to further evaluate this treatment. The involvement of the thymus in autoimmune diseases is well-established, particularly in myasthenia gravis where thymectomy is often an effective treatment [ 4 ]. Given the known role of the thymus in other...

...-aspartate (NMDA) receptor encephalitis treated with the plasma cell–depleting therapy bortezomib is reported. Summary A 5-year-old female presented to the hospital with a 1-week history of altered mental status, agitation, and possible seizure-like activity. She was admitted to the hospital...

... commentary on this article . Antibodies against the NR1 subunit of the NMDA receptor are suspected to underlie anti-NMDA receptor encephalitis. Kreye et al. provide direct evidence by showing that monoclonal human NR1 antibodies are sufficient to downregulate synaptic NMDA receptors. They show...

... is not a hallmark of these diseases, and should raise doubts of this diagnosis. Completely normal MRI scans do not exclude paraneoplastic syndromes of the CNS. Also, for some encephalitic syndromes with neuronal cell-surface antibodies (e.g. anti-NMDA receptor encephalitis), MRI imaging is very often without...

... characteristics and treatment of the primary childhood IBrainDs. inflammatory brain disease childhood primary angiitis of the central nervous system Rasmussen encephalitis NMDA receptor encephalitis neuromyelitis optica multiple sclerosis neurosarcoidosis Inflammation is an increasingly recognized...

... underlying the neurologic dysfunction are varied and include vasculitis (Behçets, Susac’s), encephalitis (NMDA receptor encephalitis), channelopathies (myasthenia, LEMS) and even an inflammatory granulomatous disease (neuro-sarcoid). The resulting syndromes cover myriad aspects of clinical neurology...