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Journal Article
Massive Thymic Hyperplasia in Graves Disease
Christopher Chan and others
JCEM Case Reports, Volume 3, Issue 6, June 2025, luaf076, https://doi.org/10.1210/jcemcr/luaf076
Published: 08 May 2025
..., distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms. Abstract Thymic hyperplasia (TH) is a rare but established complication of Graves disease (GD). It is a benign phenomenon that regresses with appropriate treatment of GD...
Journal Article
Hyperthyroidism From Graves Disease Relapsed as Hot Nodule
Suemi Marui and others
JCEM Case Reports, Volume 3, Issue 6, June 2025, luaf074, https://doi.org/10.1210/jcemcr/luaf074
Published: 25 April 2025
... declared. Figure 1. Cross indicates the patient' suprasternal notch. (A) 24-hour thyroid radioactive iodine test revealed high uptake (57%; normal reference: 8%-32%) and a diffuse distribution, strengthening the diagnosis of Graves disease. (B) A 24-hour thyroid radioactive iodine test showed high...
Journal Article
Rare Autoimmune Pancytopenia Due to Graves Disease
Ally W Wang and others
JCEM Case Reports, Volume 3, Issue 6, June 2025, luaf032, https://doi.org/10.1210/jcemcr/luaf032
Published: 23 April 2025
...Ally W Wang; Geeti Mahajan; Aaron Etra; Shira R Saul Graves disease can be associated with hematological abnormalities including isolated anemia (most common), thrombocytopenia, leukopenia, or pancytopenia (rare). Hematology consultation should be considered when cytopenias are present...
Journal Article
A Preclinical State of Graves' Ophthalmopathy Characterized by Hypoxia of T-cells Identified via Multiomics Analysis
Meng Zhang and others
The Journal of Clinical Endocrinology & Metabolism, dgaf230, https://doi.org/10.1210/clinem/dgaf230
Published: 11 April 2025
..., clinical activity score; GH, Graves' hyperthyroidism; GO, Graves' ophthalmopathy; TGAb, thyroglobulin antibodies; TMAb, thyroid microsomal antibodies; TPOAb, thyroid peroxidase antibodies; TRAb, thyroid receptor antibodies. aGH patients diagnosed with GH and no ophthalmopathy were...
Journal Article
Occurrence of Newly Diagnosed Thyroid Cancer Is Not Increased After Radioactive Iodine Therapy for Graves' Disease
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Shigenori Hiruma and others
The Journal of Clinical Endocrinology & Metabolism, dgaf231, https://doi.org/10.1210/clinem/dgaf231
Published: 11 April 2025
...-publication-reuse-rights ) Abstract Context An analysis based on a large number of detailed patient data was performed to accurately assess the impact of radioiodine therapy (RAIT) for Graves' disease (GD) on thyroid cancer. Objective The purpose was to investigate whether the occurrence of newly...
Journal Article
Prosthetic mitral valve thrombosis associated with new-onset hyperthyroidism due to Graves’ disease: a case report
Hasan Hadzalic and others
European Heart Journal - Case Reports, Volume 9, Issue 4, April 2025, ytaf184, https://doi.org/10.1093/ehjcr/ytaf184
Published: 10 April 2025
... fibrillation 1 , 2 ; however, none of these factors were present in our patient. Instead, we considered the prosthetic valve thrombosis a complication of Grave’s disease and treated it accordingly with continuation of the thyreostatic treatment and initiation of oral anticoagulation. The patient’s...
Journal Article
Teprotumumab Improves Quality of Life in Thyroid Eye Disease: Meta-analysis and Matching-adjusted Indirect Comparison
George J Kahaly and others
Journal of the Endocrine Society, Volume 9, Issue 6, June 2025, bvaf063, https://doi.org/10.1210/jendso/bvaf063
Published: 08 April 2025
... steroid” AND “thyroid eye disease” OR “Graves’ ophthalmopathy” OR “endocrine ophthalmopathy” OR “Graves’ orbitopathy.” Additionally, manual searches were conducted to identify any published articles not captured through electronic searches. Only human-based and English-language studies were included...
Journal Article
Transient Neonatal Hypothyroidism Followed by Hyperthyroidism Due to Maternal Thyrotropin Receptor Antibodies
Mark Garrelfs and others
JCEM Case Reports, Volume 3, Issue 3, March 2025, luaf040, https://doi.org/10.1210/jcemcr/luaf040
Published: 07 March 2025
... in Graves’ disease but are also found in a percentage of women with Hashimoto disease. Properties of the dominant TRAb type (stimulating or blocking) will generally dictate the clinical picture. We describe a rare case of neonatal hypothyroidism followed by hyperthyroidism caused by maternal TRAbs...
Journal Article
Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case–Control Study in Sweden
David Bergman and others
The Journal of Clinical Endocrinology & Metabolism, dgaf140, https://doi.org/10.1210/clinem/dgaf140
Published: 05 March 2025
... colitis (LC), is an inflammatory condition of the colon, characterized by watery diarrhea. Previous studies suggest an association between autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves disease) and MC; however, large-scale histology studies are lacking. Objective To assess...
Journal Article
Clinical Phenotype of Graves Disease in Autoimmune Polyglandular Syndrome or as Isolated Disease: The GRAPHE Study
Elisa Gatta and others
The Journal of Clinical Endocrinology & Metabolism, dgaf144, https://doi.org/10.1210/clinem/dgaf144
Published: 01 March 2025
... ± 20.6 11.5 ± 13.4 .918 Thyroid volume, mL 32 (14-96) 33 (14-99) 32 (13-87) .763 Graves orbitopathy (GO) 29.5% 34.7% 15.7% <.001 Active GO (CAS ≥ 3) 20.5% 24.9% 7.9% .058 GO severity Mild 8.9% 8.8% 12.2% <.001 Moderate 14.3% 18.3% 0.9% Severe 6.3% 7.6...
Journal Article
Single-Cell Landscape of Peripheral Blood Mononuclear Cells in Patients With Graves Disease
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Yixuan Wang and others
Endocrinology, Volume 166, Issue 4, April 2025, bqaf038, https://doi.org/10.1210/endocr/bqaf038
Published: 25 February 2025
... Context Graves disease (GD) is a thyroid-specific autoimmune disease and the most common cause of hyperthyroidism. Its pathogenesis is associated with the disruption of immune tolerance and autoantibody production. However, the mechanisms underlying immune abnormalities remain incompletely elucidated...
Journal Article
Inhibition of TSH Receptor Expression by a Cyclotriazadisulfonamide as a Potential Treatment of Graves Hyperthyroidism
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Christine C Krieger and others
Endocrinology, Volume 166, Issue 4, April 2025, bqaf037, https://doi.org/10.1210/endocr/bqaf037
Published: 18 February 2025
... by (a) US Government employee(s) and is in the public domain in the US. See the journal About page for additional terms. Abstract Graves hyperthyroidism (GH) is a condition in which autoantibodies chronically activate the thyrotropin (TSH) receptor (TSHR). TSHR is one of the few G protein–coupled receptors...
Journal Article
Predictive Performance of 2 Immunoassays in Patients with Graves Disease Undergoing Radioiodine Therapy: Prospective Study
Marcus Vinícius Rodrigues de Souza and others
Journal of the Endocrine Society, Volume 9, Issue 3, March 2025, bvaf016, https://doi.org/10.1210/jendso/bvaf016
Published: 31 January 2025
... Radioactive iodine (RAI) treatment is a well-established successful treatment for Graves disease (GD) but causes an increment in autoantibodies, particularly TSH receptor antibodies. Objective To assess the performance and prognostic role of Immulite thyroid-stimulating immunoglobulin (TSI) and Elecsys...
Journal Article
Concomitant Exacerbation of Graves Orbitopathy and Double-Seronegative Myasthenia Gravis after SARS-CoV-2 Infection
Yuto Nakano and others
JCEM Case Reports, Volume 3, Issue 2, February 2025, luaf019, https://doi.org/10.1210/jcemcr/luaf019
Published: 29 January 2025
... exacerbation of Graves orbitopathy (GO) and myasthenia gravis (MG) after SARS-CoV-2 infection. A 43-year-old woman had diplopia, proptosis, and swollen eyelids. Blood tests showed thyrotoxicosis and positive thyroid-stimulating hormone receptor antibodies, and orbital magnetic resonance imaging (MRI) showed...
Journal Article
Treatment of Hyperthyroidism in Graves' Disease Complicated by Thyroid Eye Disease
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Luigi Bartalena and Terry J Smith
The Journal of Clinical Endocrinology & Metabolism, Volume 110, Issue 4, April 2025, Pages 922–930, https://doi.org/10.1210/clinem/dgaf009
Published: 09 January 2025
... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Thyroid eye disease (TED) is the most consequential extrathyroidal manifestation or complication of Graves...
Journal Article
Stimulation of Piezo1 Mechanosensitive Channels Inhibits Adipogenesis in Thyroid Eye Disease
Erika Galgoczi and others
The Journal of Clinical Endocrinology & Metabolism, dgae899, https://doi.org/10.1210/clinem/dgae899
Published: 02 January 2025
... Yoda1 PPARγ Graves orbitopathy Hungarian National Research, Development and Innovation Office K143464 Ministry of Innovation and Technology of Hungary National Research, Development and Innovation Fund 10.13039/501100012550 K_22 Thyroid eye disease (TED) is an autoimmune...
Journal Article
Significance of Thyroid-Stimulating Immunoglobulin and Thyrotropin Receptor Antibody in Graves Disease
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Rongguang Peng and others
The Journal of Clinical Endocrinology & Metabolism, dgae892, https://doi.org/10.1210/clinem/dgae892
Published: 23 December 2024
... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Context Thyroid-stimulating immunoglobulin (TSI) and thyrotropin receptor antibody (TRAb) are specific biomarkers for Graves disease (GD...
Journal Article
Unusual Management of a Rare Case of Methimazole-Resistant Graves Disease
Michael Tang and others
JCEM Case Reports, Volume 3, Issue 1, January 2025, luae235, https://doi.org/10.1210/jcemcr/luae235
Published: 19 December 2024
... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. See the journal About page for additional terms. Abstract As the leading cause of hyperthyroidism, Graves disease (GD) does not often present with its classical...
Journal Article
Comprehensive Comparisons of Different Treatments for Active Graves Orbitopathy: A Systematic Review and Bayesian Model–Based Network Meta-Analysis
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Yanlin Xu and others
The Journal of Clinical Endocrinology & Metabolism, dgae877, https://doi.org/10.1210/clinem/dgae877
Published: 16 December 2024
...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Context Graves orbitopathy is a specialized immunoinflammatory disorder related to abnormal thyroid function. Due to the complexity of the disease and its propensity to reoccur, targeted treatment is essential to improve the symptoms...
Journal Article
Relation between Helicobacter pylori Infection and Autoimmune Thyroid Disease in a Sample of Pediatric Patients
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Mostafa Mohammed Mabrouk Attallah and others
QJM: An International Journal of Medicine, Volume 117, Issue Supplement_2, October 2024, hcae175.816, https://doi.org/10.1093/qjmed/hcae175.816
Published: 20 November 2024
...Mostafa Mohammed Mabrouk Attallah; Nermine Hussein Amr; Randa Ismail Khalaf; Marwa Magdy Hassan autoimmune thyroid diseases Graves’ disease Hashimoto thyroiditis Children H. Pylori Abstract Background Autoimmune thyroid diseases (ATDs) are heterogeneous group of acquired disorders...
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