... of diverse signals and signaling molecules, including the Ret tyrosine kinase receptor. Finally, Hoxb1 synergizes with exogenous Glial cell line-derived neurotrophic factor (GDNF) to strengthen Ret expression and further promote the generation of FBM-like progenitors. Facial branchiomotorneuron-like...

...) of lesioned rats. Unilateral LIPUS stimulation did not increase brain-derived neurotrophic factor in the striatum and SNpc of lesioned rats. In contrast, unilateral LIPUS stimulation increased glial cell line-derived neurotrophic factor (GDNF) protein 1.98-fold unilaterally in the SNpc. Additionally, LCN2...

...-derived neurotrophic factor (GDNF) has long been known for its potent trophic action on mesencephalic DA neurons ( Lin et al., 1993 ; Kordower and Bjorklund, 2013 ). GDNF binds to GDNF family receptor α1 (GFRα1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent...

...) sections of the MDS-UPDRS score, and (iii) assessing the performance of the PDCORE in a separate earlier randomized, placebo-controlled study of GDNF in patients with Parkinson’s disease ( Lang et al., 2006 ). Abstract There is an increasing need for improved endpoints to assess clinical trial...

... Spermatogonial stem cells (SSCs) undergo continuous self-renewal division in response to self-renewal factors. The present study identified ephrin type-A receptor 2 (EPHA2) on mouse SSCs and showed that supplementation of glial cell-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2), which...

... to phosphorylate AKT3 and subsequently enhanced the expression levels of N-myc and cyclin family in FGSCs to promote self-renewal. Moreover, glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3...

... infusions and device safety had been developed previously ( Bienemann et al., 2012 ; Barua et al., 2013 , 2016 ; Gill et al., 2013 ). Altogether, the study entered uncharted territory in several areas. The study results, while of primary relevance to GDNF and Parkinson’s...

... be addressed to: Joost Verhaggen E-mail: [email protected] Figure 1 Eggers et al. show that time-restricted GDNF gene therapy with an immune-evasive gene switch in a longitudinal rat spinal lesion model promotes motoneuron survival...

... transfected with siNC, siNEAT1, or siNEAT1 together with miR-196a-5p inhibitor, and in SW480 cells transfected with pcDNA-NC, pcDNA-NEAT1, or pcDNA-NEAT1 together with miR-196a-5p mimics, respectively. U6 was used as control. **P < 0.01. Figure 4. miR-196a-5p regulated GDNF in CRCs  (A) qRT-PCR...

..., we tested glial cell-derived neurotrophic factor (GDNF) treatment and fetal lumbar cell transplantation for their effectiveness to prevent motoneuron death and muscle atrophy after the spinal root avulsion and delayed reimplantation. Application of exogenous GDNF to injured spinal cord greatly...

... and analysis of human testes or testis biopsies. We also analyzed GDNF mRNA expression in testes of 60- to 90-day old Bl6SJL/J male mice. Prior to organ collection animals were sacrificed by asphyxiation with CO₂ and cervical dislocation. The Institutional Animal Care and Use Committee of Johns...

... into the developmental mechanisms of the nervous system as well as contribute to the establishment of novel therapies for neurodegenerative diseases. In this article, we will review the recent progress made in research of retrograde trafficking and discuss its physiological significance. GDNF neurodegenerative disease...

...S. Streiter; B. Fisch; B. Sabbah; A. Ao; R. Abir neurotrophins GDNF VIP neuronal growth factor receptors ovary The neurotrophins (NTs) are a family of small polypeptide growth factors, first recognized for their role in the peripheral and central nervous systems ( Ibanez, 1995 ). The NT...

... and peripherally by hormonal regulation. In the present study, we focus on the Gdnf-Gfra1 pathway that plays a major role in the regulation of SSC self-renewal in mammals. We describe a complex evolution of the genes encoding for Gdnf and Gfra1 proteins in trout with the emergence of three gdnf and two...

... in order to characterize cells in vitro afterward. As GDNF is the main factor known to maintain SSCs in vitro in mammals, the ability of GFRa1 to link human recombinant GDNF was studied in silico and revealed the conservation of most amino acids involved in this interaction. Surprisingly, no GDNF sequence...

...Nicole Parker; Hayley Falk; Dolly Singh; Anthony Fidaleo; Benjamin Smith; Michael S. Lopez; Kevan M. Shokat; William W. Wright We used the same histological sections described above to determine if 5, 7, or 9 days of inhibited GDNF signaling caused a loss of progenitor spermatogonia prior to loss...

... by the American Association of Neuropathologists, Inc. 2014 Epidermis Glial cell–derived neurotrophic factor (GDNF) Growth cones Growth cone turning Hepatocyte growth factor (HGF) Nonpeptidergic sensory neurons PTEN Regeneration In adults, the ongoing growth and plasticity of sensory axons...

... found that exogenous expression of GDNF transduced by adeno-associated virus (AAV) in the host striatum overcame what was suspected to be a nonpermissive growth environment, increased the survival of ectopically placed fetal VM grafts by several fold, elicited highly directional axonal outgrowth [ 20...

...Vanesa Sanchez-Guajardo; Ambra Annibali; Poul Henning Jensen; Marina Romero-Ramos CD4 cells Foxp3 GDNF Major histocompatibility complex molecules Microglia Parkinson disease Vaccination Evidence suggests that microglial activation and adaptive immunity may be an important factor in Parkinson...

... renal stones; other signs may also be renal acidification and concentration defects, pre-calyceal duct ectasias (erroneously diagnosed as cysts) and neglected proximal tubular defects. MSK is generally considered a sporadic disorder. GDNF medullary sponge kidney nephrolithiasis renal tubular...