... ligand (APRIL) signaling (TACI-Fc + AMR). Pathological changes were assessed using hematoxylin–eosin and immunohistochemical staining. Banff values were evaluated using the Banff 2015 criteria. Donor-specific antibody (DSA) levels were assessed using flow cytometry, and BAFF and APRIL concentrations were...

... ligand (APRIL), a tumour necrosis factor (TNF) superfamily cytokine involved in B-cell signalling [ 20 , 21 ], and its function in driving IgA class switch recombination and production [ 22 ] and survival of IgA-secreting plasma cells [ 23 ] has become increasingly acknowledged as likely to play a key...

...Yasuhiro Shimojima; Dai Kishida; Takanori Ichikawa; Ryota Takamatsu; Shun Nomura; Yoshiki Sekijima Serum samples were stored at −80 °C until ELISA was performed. We used ELISA kits for measuring serum concentrations of BAFF (R&D system, Minneapolis, MN, USA), APRIL (eBioscience, Vienna, Austria...

... ligand (APRIL), a key factor from the TNF superfamily for PC homeostasis, in eosinophils from the lower intestine. We observed a strong heterogeneity, since duodenum eosinophils did not produce APRIL at all, whereas a large majority of eosinophils from the ileum and right colon produced...

...Mateusz Marcisz; Bertrand Huard; Agnieszka G Lipska; Sergey A Samsonov Abstract A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily. APRIL is quite unique in this superfamily for at least for two reasons: (i) it binds to glycosaminoglycans (GAGs) via its...

...-term treatment with atacicept 150 mg in SLE patients had an acceptable safety profile, with durable efficacy. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov , NCT02070978. systemic lupus erythematosus atacicept TACI APRIL/BLyS inhibitor long-term extension study EMD Serono...

... provide evidence that aberrant mucosal immune responses to tonsillar anaerobic microbiota, primarily consisting of members of the phylum Bacteroidetes, are involved in IgAN pathophysiology. APRIL IgA nephropathy immunoglobulin repertoire sequencing microbiome tonsillectomy KEY LEARNING POINTS...

... macrophages, a membrane-bound form of APRIL (Stalk-1) for APRIL-producing cells and a soluble form of APRIL (Aprily-8) for secreted APRIL. The immunostaining was performed using a monoclonal antibody against human IgG4 (clone HP6025, fully diluted; Nichirei, Tokyo, Japan), CD138 (clone B-B4, 1:100; AbD...

... concentration of B-cell activating factors, B lymphocyte stimulators (BLyS), and a proliferation-inducing ligand (APRIL) in Behçet disease (BD) patients in order to evaluate their role and study their relation to uveitis subtype and disease activity. Methods The study included 58 consecutively...

.../open_access/funder_policies/chorus/standard_publication_model ) Mod Rheumatol (2012) 22:541 549 DOI 10.1007/s10165-011-0539-z ORIGINAL ARTICLE Effects of APRIL (TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL Takumi Furuya Minori Koga Koki Hikami Aya Kawasaki Naoyuki...

... survival factors BAFF and APRIL in mucosa from patients with GPA. We detected APRIL production by the granulomas and giant cells. B cells were proliferating in all cases and persistent for 5 years in biopsies obtained from one patient. However, there was no evidence of B-cell clones from the mucosal...

... IL-21, pg/ml 261.2 (272.6) 1122.0 (3170.0) 1617.0 (3415.0) 1226.0 (1158.0) 464.7 (1178.0) 246.5 (478.7) 548.3 (454.7) APRIL, ng/ml 6.0 (11.3) 18.8 (19.7) 12.5 (8.7) 23.2 (29.9) 5.9 (5.2) 13.1 (27.6) 26.2 (25.8) BAFF, ng/ml 0.3 (0.6) 0.8 (0.6) 0.5 (0.2) 0.8 (0.3) 0.3 (0.4...

.... These ndings leukemia cells,7) but its anticancer function, especially suggest that BME has possible therapeutic potential in its anti-tumor-proliferative activity, has not been de ned hepatoma cancer patients and that depletion of cellular thus far. APRIL is an important mechanism in the growth- inhibitory e...

... of Appeal of 13 April 2006 and the Antwerp Court of Appeal of 19 December 2005 reflect this division. Practical significance There can be no doubt that legal security is under serious threat, both from the developers of software and from potential infringers. The time is right to put a preliminary...

...Y. H. Lee; F. Ota; X. Kim-Howard; K. M. Kaufman; S. K. Nath Interestingly, the APRIL gene is located on chromosome 17p13.1, a genomic location that has been known to be the linkage area in European-American families with vitiligo-related SLE and the hypothetical putative gene is known...

..., Tsukuba, Ibaraki 305-8575, Japan. E-mail: [email protected] 5 11 2006 9 1 2007 While the role of BLyS in B cell survival, differentiation and activation is established, functions of APRIL remain less defined. Recombinant APRIL stimulates B and T cell proliferation [ 7 ] and APRIL...

..., SOCS1 expression during DC maturation plays a role in surveillance in controlling the aberrant expansion of abnormal DC subset to maintain homeostasis of immune system. antigen presentation CD8 dendritic cell SOCS1 APC    antigen-presenting cell APRIL    a proliferation-inducing ligand BLyS/ BAFF...

...Min Zhang; King-Hung Ko; Queenie Lai Kwan Lam; Cherry Kam Chun Lo; Gopesh Srivastava; Bojian Zheng; Yu-Lung Lau; Liwei Lu apoptosis autoimmunity B lymphocytes cytokine dendritic cells APRIL    a proliferation-inducing ligand BAFF    B cell activation factor BAFF-R    B cell activation factor...

... to PCs. BAFF BAFF receptors B cell differentiation follicular dendritic cells APRIL    a proliferation-inducing ligand BAFF    B cell-activating factor of the tumor necrosis factor family BCMA    B cell maturation antigen CD40L    CD40 ligand DAPI    4′,6-diamidino-2-phenylindole DRC-1...

...T. Koyama; H. Tsukamoto; K. Masumoto; D. Himeji; K. Hayashi; M. Harada; T. Horiuchi 8 1 2003 2 9 2002 © British Society for Rheumatology 2003 Abstract Objective. We investigated the association of gene polymorphisms in APRIL, a new member of the TNF family...