... stress could be efficiently controlled by the induction of antioxidant defenses. pharmaceuticals reproductive toxicity aquatic invertebrates Page 1 of 28 Environmental Toxicology and Chemistry 1 2 3 Zanitti et al. 4 5 6 Environmental Toxicology 7 8 Diclofenac activates antioxidant defenses and affects...

... [email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Pharmaceuticals in polluted water can harm humans, animals, and marine life...

...% confidence and is described within the FDA’s Guidance for Industry #3. analytical chemistry avian toxicity pharmaceuticals wildlife toxicology Park Cities Quail Coalition Rolling Plains Quail Research Foundation 10.13039/100017988 The northern bobwhite (Colinus virginianus; hereafter...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Chiral pharmaceuticals, racemic or enantiomerically pure forms and their metabolites, can reach aquatic ecosystems via wastewater effluents...

... to exist as ionic species when dissolved in a variety of biological matrices. In many cases a compound’s acidity or basicity can contribute of some drug properties, such as lipophilicity ( Charifson & Walters, 2014 ). Therefore, the pH level of pharmaceuticals that have been detected in this study were...

... with the guidelines and regulations in the Guide for the Care and Use of Laboratory Animals: Eighth Edition. Corresponding author. Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. E-mail: [email protected] 02 08 2024 03 12...

... electrophysiology ion channels pharmaceuticals Takeda Development Center Americas 10.13039/100031585 Among the most severe FDA “black box warnings” of neurotoxicity reported on drug labels, seizure/convulsion is listed within the top 4, behind suicidal ideation, sedation, and abuse liability ( Walker et al. 2018...

... Toxicol Chem 2024;43:2569–2577. © 2024 SETAC Environmental chemistry Illicit drug consumption Municipal effluents Pharmaceuticals Population modeling Rural wastewater The issue of illicit drug abuse is increasingly acknowledged as a significant challenge globally. With the number of drug users...

..., short half‐life, and incomplete metabolism, metoprolol can be inadvertently introduced into both freshwater and marine environments. Perhaps the most significant pathway of introduction is incomplete removal and elimination of the pharmaceutical by wastewater treatment plants (Rutere et al.,  2021...

... 2024 Copyright © 2024 SETAC. 2024 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights) Abstract Pharmaceuticals in aquatic environments pose threats to aquatic...

.... This article should be helpful in discussing these issues with your physicians and should enhance your understanding of the potential for abuse or misuse in the context of pain management.” (Email from Medical Services, Product Management, Sales Training, Janssen Pharmaceuticals to Sales Force ) 3...

... to include monitoring and control of these compounds in aquatic systems. Environ Toxicol Chem 2024;43:2199–2210. © 2024 SETAC Emerging contaminants Environmental risk assessment Methylparaben Pharmaceuticals Pollution Pharmaceuticals and personal care products (PPCPs) Fundação de Amparo...

... as feasible but unlikely to reduce specialty drug costs. Based on these results, we offer 4 recommendations to policymakers considering ways to reduce specialty drug costs. pharmaceuticals costs and spending specialty drugs National Institute for Health Care Reform RAND 10.13039/100004459 Over...

... dispensing, handling, and disposal of unused, expired, or patient-specific medication doses [ 1–3 , 5 ]. Search and screening strategies are shown in Figure 1 . Twelve studies were found in the literature discussing pharmaceutical waste in either pediatric or adult healthcare settings for inclusion...

...://creativecommons.org/licenses/by/4.0/ ), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Pharmaceuticals have been classified as an environmental concern due to their increasing consumption globally and potential environmental...

... of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read...

... pharmaceuticals. All chemicals applied were at least of analytical purity (≥95%). Table S1 provides a list that includes CAS numbers, structures, and chemical suppliers for the micropollutants applied in this study. Solvents (HPLC-MS grade water, methanol (Lichrosolv®) and formic acid were obtained from Merck...

... to VFX. Abstract Wastewater treatment plant (WWTP) effluent often releases pharmaceuticals like venlafaxine (a serotonin–norephinephrine reuptake inhibitor antidepressant) to freshwater ecosystems at levels causing adverse metabolic effects on fish. Changes to fish metabolism can be regulated...

... University Press, Standard Journals Publication Model (https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights) Abstract Pharmaceuticals and drugs of abuse are organic micropollutants of emerging concern in both surface and groundwater worldwide. These compounds are considered to be pseudo...

... the permanent and the temporary populations have increased significantly in recent decades, and this has not necessarily been accompanied by an improvement in sewage networks. Emerging micropollutants such as pharmaceutical compounds reach aquatic systems directly, in the absence of a domestic sewage network...