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1-20 of 27
Authors: Frank D Sistare
Journal Article
A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures Get access
Toxicology Research, Volume 13, Issue 1, February 2024, tfad120, https://doi.org/10.1093/toxres/tfad120
Published: 11 January 2024
Journal Article
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies Open Access
Toxicological Sciences, Volume 188, Issue 1, July 2022, Pages 4–16, https://doi.org/10.1093/toxsci/kfac041
Published: 11 April 2022
Journal Article
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin Free
Toxicological Sciences, Volume 187, Issue 2, June 2022, Pages 219–233, https://doi.org/10.1093/toxsci/kfac030
Published: 14 March 2022
Journal Article
FEATURED
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats Free
Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 148–159, https://doi.org/10.1093/toxsci/kfab038
Published: 09 April 2021
Journal Article
Mechanistic Investigations Support Liver Safety of Ubrogepant Open Access
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 84–93, https://doi.org/10.1093/toxsci/kfaa093
Published: 24 June 2020
Journal Article
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury Open Access
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 281–299, https://doi.org/10.1093/toxsci/kfaa088
Published: 19 June 2020
Journal Article
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline Free
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 121–139, https://doi.org/10.1093/toxsci/kfaa094
Published: 19 June 2020
Journal Article
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities Get access
Toxicological Sciences, Volume 175, Issue 1, May 2020, Pages 98–112, https://doi.org/10.1093/toxsci/kfaa026
Published: 02 March 2020
Journal Article
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3 Get access
Toxicological Sciences, Volume 172, Issue 1, November 2019, Pages 155–166, https://doi.org/10.1093/toxsci/kfz186
Published: 12 August 2019
Journal Article
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats Get access
Toxicological Sciences, Volume 171, Issue 1, September 2019, Pages 46–55, https://doi.org/10.1093/toxsci/kfz125
Published: 25 May 2019
Journal Article
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity Get access
Toxicological Sciences, Volume 170, Issue 1, July 2019, Pages 180–198, https://doi.org/10.1093/toxsci/kfz079
Published: 23 March 2019
Journal Article
A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury Get access
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 110–125, https://doi.org/10.1093/toxsci/kfy282
Published: 28 November 2018
Journal Article
Response of Novel Skeletal Muscle Biomarkers in Dogs to Drug-Induced Skeletal Muscle Injury or Sustained Endurance Exercise Get access
Toxicological Sciences, Volume 156, Issue 2, April 2017, Pages 422–427, https://doi.org/10.1093/toxsci/kfw262
Published: 23 January 2017
Journal Article
Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition Get access
Toxicological Sciences, Volume 157, Issue 1, May 2017, Pages 30–40, https://doi.org/10.1093/toxsci/kfx015
Published: 20 January 2017
Journal Article
The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development Free
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ILAR Journal
ILAR Journal, Volume 57, Issue 2, 1 December 2016, Pages 186–211, https://doi.org/10.1093/ilar/ilw025
Published: 04 January 2017
Journal Article
Developing a T cell:Dendritic cell co-culture system to predict idiosyncratic drug induced hypersensitivity reactions Get access
The Journal of Immunology, Volume 196, Issue 1_Supplement, May 2016, Page 194.10, https://doi.org/10.4049/jimmunol.196.Supp.194.10
Published: 01 May 2016
Journal Article
Evaluation of the Relative Performance of 12 Urinary Biomarkers for Renal Safety Across 22 Rat Sensitivity and Specificity Studies Get access
Toxicological Sciences, Volume 138, Issue 1, March 2014, Pages 3–20, https://doi.org/10.1093/toxsci/kft330
Published: 21 December 2013
Journal Article
EDITOR'S CHOICE
A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase Get access
Toxicological Sciences, Volume 130, Issue 2, December 2012, Pages 229–244, https://doi.org/10.1093/toxsci/kfs243
Published: 07 August 2012
Journal Article
Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury Get access
Clinical Chemistry, Volume 55, Issue 11, 1 November 2009, Pages 1977–1983, https://doi.org/10.1373/clinchem.2009.131797
Published: 01 November 2009
Journal Article
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats Open Access
Nucleic Acids Research, Volume 33, Issue 22, 1 December 2005, Page e187, https://doi.org/10.1093/nar/gni186
Published: 01 January 2005
