149. PULMONARY PRESENTATIONS IN TAKAYASU ARTERITIS Free

Background: Takayasu arteritis (TA) is a chronic granulomatous large vessel vasculitis. Recently, we found some patients had lung involvement that can’t be explained by other causes. The present study aimed to investigate lung involvement in patients with TA by high-resolution computed tomography (HRCT).

Methods: In this study, 142 TA patients with complete clinical information including HRCT and interferon-gamma release assays (IGRA) before treatment and 156 normal controls with HRCT for physical examination were enrolled. Among them, patients with confirmed diagnosis of pulmonary disorder (i.e., infections, tumor, except tuberculosis) have been excluded. Patients with TA were divided into tuberculosis subgroup, non-tuberculosis subgroup and normal subgroup based on their clinical

Background: HRCT presentations and IGRA under the collaboration of rheumatologists and experienced radiologists. Various clinical data including pulmonary presentations and laboratory parameters were analyzed to illustrate potential mechanism.

Results: TA patients and healthy controls enrolled were gender and age-matched (female: male ratio, 112:30 vs. 128:28; P = 0.56; 36.86 ± 13.50 years vs. 38.46 ± 6.91 years, P = 0.19). Compared with control group, the frequencies of stripe/patchy shadows (52/142 vs 34/156), unilateral thoracic effusion (6/142 vs 0/156), pulmonary arterial involvement (12/142 vs 0/156) et al were more common in patients with TA (P < 0.05). Patients with TA were divided into tuberculosis subgroup (19, 13.38%), non-tuberculosis subgroup (73, 51.41%) and normal subgroup (50, 35.21%). Various abnormal HRCT findings were also observed in non- tuberculosis subgroup such as nodule (30, 41.10%), stripe/patchy shadows (42, 57.53%) and pleural effusion (8, 10.96%). Compared with normal subgroup, patients with abnormal lung HRCT findings had significantly lower Ts cell proportions (26.86 ± 8.53 vs 31.18 ± 13.47, P = 0.03). Patients with non- tuberculosis lesions were older than patients with normal lungs (43.31 ± 14.51 years vs. 35.16 ± 12.28 years; P = 0.006) and had lower hemoglobin level (113.17 ± 22.98 vs. 122.24 ± 19.94, P = 0.03). Patients with tuberculosis had a higher percentage of weight loss (7/19 vs. 2/50; P < 0.001) and a higher proportion of blood NK cells than patients with normal lungs (11.23 ± 5.00 vs. 8.30 ± 4.73, P = 0.03).

Conclusion: Besides tuberculosis-related pulmonary lesions, TA itself can have pulmonary parenchymal abnormalities, which probably are part of non-specific systemic inflammation of TA and should arouse physician’s attention.

Disclosures: This work was supported by the National Natural Science Foundation of China [grant number 81571571].