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Gabriel S. Panayi, Developments in the immunology of rheumatoid arthritis, a personal perspective, Rheumatology, Volume 50, Issue 5, May 2011, Pages 815–817, https://doi.org/10.1093/rheumatology/ker024
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The cells behind the disease
A 50th anniversary is an auspicious date. In 50 volumes, Rheumatology has published many important papers in all the major areas of rheumatology. In this editorial, I shall review what I consider to be the important landmarks in the development of our understanding of the immunology, and hence the immunotherapy of RA over this time. My account should be read with caution. Apart from personal prejudice, which I shall try to avoid, there is the inevitable prejudice that we interpret the past with the preoccupations of the present.
My interest in the immunology of RA arose as a consequence of working with Professor Dudley Dumonde at the Kennedy Institute of Rheumatology on lymphokines, non-antibody mediators of T-cell activity [1]. This led me to dedicate my research work to investigating the function of T cells in the pathogenesis of RA in the firm belief that manipulating T-cell responses would lead to more effective and specific therapies.
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