-
Views
-
Cite
Cite
Claire Murphy, Maria E. Gregory, Kanna Ramaesh, Peripheral ulcerative keratitis: an unusual primary ocular manifestation in Behçet's disease?, Rheumatology, Volume 48, Issue 12, December 2009, Page 1490, https://doi.org/10.1093/rheumatology/kep232
Close - Share Icon Share
Extract
Ocular involvement occurs in 50–70% of the patients with Behçet's disease [1]. A 22-year-old Caucasian woman with Behçet's disease presented with bilateral vasculitic peripheral ulcerative keratitis (PUK) two months after oral and genital ulceration, which was the earliest manifestation. The circular ulcers involved the inferonasal cornea bilaterally (Fig. 1). Visual acuity was 6/9, intraocular pressure was normal and there was no evidence of intraocular inflammation or retinal vasculitis in either eye. She had no previous ophthalmic history.
Corneal scrapings for bacteria, Acanthamoeba and fungi, and polymerase chain reaction for herpes simplex, adenovirus and herpes zoster were found to be negative. Autoimmune screen consisting of RF, ANA, ANCA and AMA was negative. The ulcers resolved with oral prednisolone and azathioprine.
Typical eye lesions described by Behçet's classification criteria include characteristic occlusive retinal vasculitis, cells in the vitreous and anterior, posterior or pan uveitis [1]. Corneal band keratopathy can occur secondary to chronic iridocyclitis, however, corneal pathology is rare in Behçet's disease. Bilateral corneal ring opacities have been described in patients with evidence of other intraocular inflammation.
Comments