https://orcid.org/0009-0001-5501-2039
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Changlong Wei, Xiaofang Wang, Cholecystectomy and cancer risk: evidence from National Health and Nutrition Examination Survey and Mendelian randomization, Postgraduate Medical Journal, Volume 101, Issue 1195, May 2025, Pages 489–491, https://doi.org/10.1093/postmj/qgae135
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Dear Editor,
Gallstones are one of the most common gastrointestinal disorders in the world, with ~5–15% of the Western population suffering from gallstones [1]. Cholecystectomy is the mainstay of treatment for gallstone disease, and the number of cholecystectomies performed is increasing every year as the prevalence of gallstones continues to grow. However, there have been numerous studies linking cholecystectomy to an increased risk of a variety of cancers, including liver, biliary tract, pancreatic, prostate, breast, and colorectal cancers [2]. As of now, there is no conclusive evidence regarding the causal relationship between cholecystectomy and a variety of cancers. Despite the fact that cholecystectomy has become a very common surgical procedure, the long-term health effects of cholecystectomy have gradually become a cause for concern. Therefore, we utilized data from the National Health and Nutrition Examination Survey (NHANES) and further used Mendelian randomization (MR) to fully explore the relationship between cholecystectomy and cancers, and we hope that our study will provide new insights into this topic.
