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DIFFERENCES IN BODY COMPOSITION, MUSCLE STRENGHT AND BIOCHEMICAL PARAMETERS IN CKD PATIENTS WITH AND WITHOUT PROTEIN ENERGY WASTING (PEW)

PEW sometimes produces irreversible alterations in nutritional status, and early diagnosis could mark the sindrome reversibility.

Aim.-To establish the prevalence of PEW in an advanced CKD unit in a sample of 325 patients with CKD and to establish the differences in nutritional parameters, body composition and muscle strength.

The patients treated in Advanced CKD Unit (ACKD) nutritional status monitoring is performed every 3 months, will be assessed through a cross-sectional , with the frequency being able to increase if malnutrition is detected in the screening.

The ISRNM criteria are applied to diagnose PEW, and the patients are classified according to whether or not they have PEW and the differences in nutritional parameters are analyzed: albumin, transferrin, CRP, linphocytes, Hb, body composition with Akhern HD-01 monofrequency BIA and anthropometric measurements and muscular strength with dynamometer (baseline).

We have evaluated 325 patients with CKD xage 70.88 ± 12.55 years, 66.8% 217pac are men with xCKD-EPI of 19.19 ± 9.28ml / min / 1.73m2 PEW prevalence 8.9% (29 patients) aged 74.06 ± 12.79 years, with no significant difference between sexes with and without PEW (18/215 men and 11/108 women). We found significant differences between the groups with PEW vs without PEW in protein intake (nPNA) 0.73 ± 0.21 vs 0.93 ± 0.26, p0.003, albumin 3.74 ± 0.66 vs 4.21 ± 0.41, CRP 1.20 ± 2.09 vs 0.68 ± 1.20, p0.05, Hb 11.33 ± 1.52 vs 11.90 ± 1.50, p0.023, transferrin 199.71 ± 48.38 vs224.95 ± 48.85, p0.013.

Data on anthropometric and body composition measures as showing in the table. The values of biochemical parameters and body composition in patients with PEW are striking, as some are close to the low limit of normality, which suggests the possible reversibility if action is taken on time.

The monitoring of nutritional status in a protocolized way provides low prevalences of PEW and allows its early detection, which favors its reversibility with the appropriate intervention.