Performance of Hemodialysis with Novel Medium Cut-Off Dialyzers, Nephrol Dial Transplant; 2016; gfw310. doi.org/10.1093/ndt/gfw310

In the original article, there were inaccuracies within the reporting of data in Table 4 and Table 5. The data was reported as mean +/− SD instead of Least Square mean +/− SE.

The correct version of Table 4 is as follows:

Table 4

(A) Overall clearances and (B) reduction ratios of medium-sized and small solutes in hemodialysis treatments in study 1

CasesMCO AA HDMCO BB HDMCO CC HDHigh-flux HD
(A) Overall clearance (mL/min)
 α1-microglobulin3.8 (0.39)*5.2 (0.37)*7.0 (0.38)*0.1 (0.37)
 Complement factor D26.5 (1.11)*30.4 (1.04)*34.6 (1.07)*1.8 (1.04)
 Myoglobin52.0 (2.48)*59.3 (2.33)*68.1 (2.47)*11.9 (2.33)
 β2-microglobulin67.9 (2.29)*71.9 (2.15)*75.7 (2.28)*26.1 (2.15)
 Creatinine159.5 (3.60)159.9 (3.50)162.6 (3.54)157.2 (3.50)
 Phosphate172.8 (4.84)*179.8 (4.74)*187.4 (4.78)*152.8 (4.74)
 Urea216.9 (4.77)**216.7 (4.65)**217.2 (4.70)**208.2 (4.65)
(B) Reduction ratio (%)
 YKL-4060.5 (1.66)*66.4 (1.66)*70.8 (1.66)*19.2 (1.69)
 α1-microglobulin21.7 (2.42)*22.6 (2.42)29.3 (2.42)*7.7 (2.48)
 Complement factor D56.9 (1.30)*61.7 (1.30)*64.4 (1.30)*16.6 (1.33)
 Myoglobin63.1 (2.09)*67.2 (2.09)*68.9 (2.14)*8.6 (2.14)
 β2-microglobulin71.5 (1.35)*72.0 (1.35)*72.1 (1.36)*53.0 (1.36)
 Creatinine64.3 (1.31)**62.9 (1.31)63.1 (1.31)62.5 (1.31)
 Phosphate58.8 (2.37)56.9 (2.37)57.6 (2.37)56.8 (2.37)
 Urea71.3 (1.22)**70.5 (1.22)71.1 (1.22)70.1 (1.22)
CasesMCO AA HDMCO BB HDMCO CC HDHigh-flux HD
(A) Overall clearance (mL/min)
 α1-microglobulin3.8 (0.39)*5.2 (0.37)*7.0 (0.38)*0.1 (0.37)
 Complement factor D26.5 (1.11)*30.4 (1.04)*34.6 (1.07)*1.8 (1.04)
 Myoglobin52.0 (2.48)*59.3 (2.33)*68.1 (2.47)*11.9 (2.33)
 β2-microglobulin67.9 (2.29)*71.9 (2.15)*75.7 (2.28)*26.1 (2.15)
 Creatinine159.5 (3.60)159.9 (3.50)162.6 (3.54)157.2 (3.50)
 Phosphate172.8 (4.84)*179.8 (4.74)*187.4 (4.78)*152.8 (4.74)
 Urea216.9 (4.77)**216.7 (4.65)**217.2 (4.70)**208.2 (4.65)
(B) Reduction ratio (%)
 YKL-4060.5 (1.66)*66.4 (1.66)*70.8 (1.66)*19.2 (1.69)
 α1-microglobulin21.7 (2.42)*22.6 (2.42)29.3 (2.42)*7.7 (2.48)
 Complement factor D56.9 (1.30)*61.7 (1.30)*64.4 (1.30)*16.6 (1.33)
 Myoglobin63.1 (2.09)*67.2 (2.09)*68.9 (2.14)*8.6 (2.14)
 β2-microglobulin71.5 (1.35)*72.0 (1.35)*72.1 (1.36)*53.0 (1.36)
 Creatinine64.3 (1.31)**62.9 (1.31)63.1 (1.31)62.5 (1.31)
 Phosphate58.8 (2.37)56.9 (2.37)57.6 (2.37)56.8 (2.37)
 Urea71.3 (1.22)**70.5 (1.22)71.1 (1.22)70.1 (1.22)

LS mean +/- standard error

Comparisons are based on a mixed model with fixed effects of period and study dialyzer type, and the random effect of subject.

*P < 0.001; **P < 0.05; (all versus HD).

Table 4

(A) Overall clearances and (B) reduction ratios of medium-sized and small solutes in hemodialysis treatments in study 1

CasesMCO AA HDMCO BB HDMCO CC HDHigh-flux HD
(A) Overall clearance (mL/min)
 α1-microglobulin3.8 (0.39)*5.2 (0.37)*7.0 (0.38)*0.1 (0.37)
 Complement factor D26.5 (1.11)*30.4 (1.04)*34.6 (1.07)*1.8 (1.04)
 Myoglobin52.0 (2.48)*59.3 (2.33)*68.1 (2.47)*11.9 (2.33)
 β2-microglobulin67.9 (2.29)*71.9 (2.15)*75.7 (2.28)*26.1 (2.15)
 Creatinine159.5 (3.60)159.9 (3.50)162.6 (3.54)157.2 (3.50)
 Phosphate172.8 (4.84)*179.8 (4.74)*187.4 (4.78)*152.8 (4.74)
 Urea216.9 (4.77)**216.7 (4.65)**217.2 (4.70)**208.2 (4.65)
(B) Reduction ratio (%)
 YKL-4060.5 (1.66)*66.4 (1.66)*70.8 (1.66)*19.2 (1.69)
 α1-microglobulin21.7 (2.42)*22.6 (2.42)29.3 (2.42)*7.7 (2.48)
 Complement factor D56.9 (1.30)*61.7 (1.30)*64.4 (1.30)*16.6 (1.33)
 Myoglobin63.1 (2.09)*67.2 (2.09)*68.9 (2.14)*8.6 (2.14)
 β2-microglobulin71.5 (1.35)*72.0 (1.35)*72.1 (1.36)*53.0 (1.36)
 Creatinine64.3 (1.31)**62.9 (1.31)63.1 (1.31)62.5 (1.31)
 Phosphate58.8 (2.37)56.9 (2.37)57.6 (2.37)56.8 (2.37)
 Urea71.3 (1.22)**70.5 (1.22)71.1 (1.22)70.1 (1.22)
CasesMCO AA HDMCO BB HDMCO CC HDHigh-flux HD
(A) Overall clearance (mL/min)
 α1-microglobulin3.8 (0.39)*5.2 (0.37)*7.0 (0.38)*0.1 (0.37)
 Complement factor D26.5 (1.11)*30.4 (1.04)*34.6 (1.07)*1.8 (1.04)
 Myoglobin52.0 (2.48)*59.3 (2.33)*68.1 (2.47)*11.9 (2.33)
 β2-microglobulin67.9 (2.29)*71.9 (2.15)*75.7 (2.28)*26.1 (2.15)
 Creatinine159.5 (3.60)159.9 (3.50)162.6 (3.54)157.2 (3.50)
 Phosphate172.8 (4.84)*179.8 (4.74)*187.4 (4.78)*152.8 (4.74)
 Urea216.9 (4.77)**216.7 (4.65)**217.2 (4.70)**208.2 (4.65)
(B) Reduction ratio (%)
 YKL-4060.5 (1.66)*66.4 (1.66)*70.8 (1.66)*19.2 (1.69)
 α1-microglobulin21.7 (2.42)*22.6 (2.42)29.3 (2.42)*7.7 (2.48)
 Complement factor D56.9 (1.30)*61.7 (1.30)*64.4 (1.30)*16.6 (1.33)
 Myoglobin63.1 (2.09)*67.2 (2.09)*68.9 (2.14)*8.6 (2.14)
 β2-microglobulin71.5 (1.35)*72.0 (1.35)*72.1 (1.36)*53.0 (1.36)
 Creatinine64.3 (1.31)**62.9 (1.31)63.1 (1.31)62.5 (1.31)
 Phosphate58.8 (2.37)56.9 (2.37)57.6 (2.37)56.8 (2.37)
 Urea71.3 (1.22)**70.5 (1.22)71.1 (1.22)70.1 (1.22)

LS mean +/- standard error

Comparisons are based on a mixed model with fixed effects of period and study dialyzer type, and the random effect of subject.

*P < 0.001; **P < 0.05; (all versus HD).

The correct version of Table 5 is as follows:

Table 5

(A) Overall clearances and (B) reduction ratios of medium-sized and small molecules in treatments in study 2

CasesMCO AA HDMCO BB HDHigh-flux HDHDF
(A) Overall clearance (mL/min)
 α1-microglobulin3.3 (0.20)*4.6 (0.20)*0.4 (0.20)1.3 (0.20)
 Complement factor D26.3 (1.13)*32.8 (1.10)*8.2 (1.10)12.4 (1.10)
 Myoglobin58.7 (2.46)*62.7 (2.39)*19.9 (2.39)35.6 (2.46)
 β2-microglobulin84.7 (3.18)**,***84.3 (3.10)**,***55.1 (3.10)73.1 (3.18)
 Creatinine210.4 (8.73)203.7 (8.31)208.9 (8.31)210.0 (8.31)
 Phosphate209.8 (11.29)218.0 (10.71)193.2 (10.71)194.5 (10.71)
 Urea281.9 (11.97)268.1 (11.32)277.0 (11.32)263.4 (11.32)
(B) Reduction ratio (%)
 YKL-4063.6 (2.21)*68.8 (2.21)*29.8 (2.21)44.8 (2.21)
 α1-microglobulin24.8 (8.97)***30.1 (8.97)***10.0 (8.97)−8.9 (8.97)
 Complement factor D63.0 (1.73)*66.7 (1.73)*32.9 (1.73)46.3 (1.73)
 Myoglobin67.9 (2.34)*71.6 (2.34)*37.2 (2.34)59.3 (2.37)
 β2-microglobulin78.5 (1.32)**,****78.9 (1.32)**73.5 (1.32)80.6 (1.33)
 Creatinine73.5 (1.45)73.2 (1.45)71.7 (1.45)73.7 (1.45)
 Phosphate52.8 (2.13)48.8 (2.13)48.4 (2.13)51.0 (2.13)
 Urea80.7 (1.33)*****80.3 (1.33)****79.4 (1.33)81.6 (1.33)
CasesMCO AA HDMCO BB HDHigh-flux HDHDF
(A) Overall clearance (mL/min)
 α1-microglobulin3.3 (0.20)*4.6 (0.20)*0.4 (0.20)1.3 (0.20)
 Complement factor D26.3 (1.13)*32.8 (1.10)*8.2 (1.10)12.4 (1.10)
 Myoglobin58.7 (2.46)*62.7 (2.39)*19.9 (2.39)35.6 (2.46)
 β2-microglobulin84.7 (3.18)**,***84.3 (3.10)**,***55.1 (3.10)73.1 (3.18)
 Creatinine210.4 (8.73)203.7 (8.31)208.9 (8.31)210.0 (8.31)
 Phosphate209.8 (11.29)218.0 (10.71)193.2 (10.71)194.5 (10.71)
 Urea281.9 (11.97)268.1 (11.32)277.0 (11.32)263.4 (11.32)
(B) Reduction ratio (%)
 YKL-4063.6 (2.21)*68.8 (2.21)*29.8 (2.21)44.8 (2.21)
 α1-microglobulin24.8 (8.97)***30.1 (8.97)***10.0 (8.97)−8.9 (8.97)
 Complement factor D63.0 (1.73)*66.7 (1.73)*32.9 (1.73)46.3 (1.73)
 Myoglobin67.9 (2.34)*71.6 (2.34)*37.2 (2.34)59.3 (2.37)
 β2-microglobulin78.5 (1.32)**,****78.9 (1.32)**73.5 (1.32)80.6 (1.33)
 Creatinine73.5 (1.45)73.2 (1.45)71.7 (1.45)73.7 (1.45)
 Phosphate52.8 (2.13)48.8 (2.13)48.4 (2.13)51.0 (2.13)
 Urea80.7 (1.33)*****80.3 (1.33)****79.4 (1.33)81.6 (1.33)

LS mean +/- standard error

Comparisons are based on a mixed model with fixed effects of period and study dialyzer type, and the random effect of subject.

*P < 0.001 versus HD and HDF; **P < 0.001 versus HD; ***P < 0.01 versus HDF; ****P < 0.05 versus HDF; *****P < 0.05 versus HD.

Table 5

(A) Overall clearances and (B) reduction ratios of medium-sized and small molecules in treatments in study 2

CasesMCO AA HDMCO BB HDHigh-flux HDHDF
(A) Overall clearance (mL/min)
 α1-microglobulin3.3 (0.20)*4.6 (0.20)*0.4 (0.20)1.3 (0.20)
 Complement factor D26.3 (1.13)*32.8 (1.10)*8.2 (1.10)12.4 (1.10)
 Myoglobin58.7 (2.46)*62.7 (2.39)*19.9 (2.39)35.6 (2.46)
 β2-microglobulin84.7 (3.18)**,***84.3 (3.10)**,***55.1 (3.10)73.1 (3.18)
 Creatinine210.4 (8.73)203.7 (8.31)208.9 (8.31)210.0 (8.31)
 Phosphate209.8 (11.29)218.0 (10.71)193.2 (10.71)194.5 (10.71)
 Urea281.9 (11.97)268.1 (11.32)277.0 (11.32)263.4 (11.32)
(B) Reduction ratio (%)
 YKL-4063.6 (2.21)*68.8 (2.21)*29.8 (2.21)44.8 (2.21)
 α1-microglobulin24.8 (8.97)***30.1 (8.97)***10.0 (8.97)−8.9 (8.97)
 Complement factor D63.0 (1.73)*66.7 (1.73)*32.9 (1.73)46.3 (1.73)
 Myoglobin67.9 (2.34)*71.6 (2.34)*37.2 (2.34)59.3 (2.37)
 β2-microglobulin78.5 (1.32)**,****78.9 (1.32)**73.5 (1.32)80.6 (1.33)
 Creatinine73.5 (1.45)73.2 (1.45)71.7 (1.45)73.7 (1.45)
 Phosphate52.8 (2.13)48.8 (2.13)48.4 (2.13)51.0 (2.13)
 Urea80.7 (1.33)*****80.3 (1.33)****79.4 (1.33)81.6 (1.33)
CasesMCO AA HDMCO BB HDHigh-flux HDHDF
(A) Overall clearance (mL/min)
 α1-microglobulin3.3 (0.20)*4.6 (0.20)*0.4 (0.20)1.3 (0.20)
 Complement factor D26.3 (1.13)*32.8 (1.10)*8.2 (1.10)12.4 (1.10)
 Myoglobin58.7 (2.46)*62.7 (2.39)*19.9 (2.39)35.6 (2.46)
 β2-microglobulin84.7 (3.18)**,***84.3 (3.10)**,***55.1 (3.10)73.1 (3.18)
 Creatinine210.4 (8.73)203.7 (8.31)208.9 (8.31)210.0 (8.31)
 Phosphate209.8 (11.29)218.0 (10.71)193.2 (10.71)194.5 (10.71)
 Urea281.9 (11.97)268.1 (11.32)277.0 (11.32)263.4 (11.32)
(B) Reduction ratio (%)
 YKL-4063.6 (2.21)*68.8 (2.21)*29.8 (2.21)44.8 (2.21)
 α1-microglobulin24.8 (8.97)***30.1 (8.97)***10.0 (8.97)−8.9 (8.97)
 Complement factor D63.0 (1.73)*66.7 (1.73)*32.9 (1.73)46.3 (1.73)
 Myoglobin67.9 (2.34)*71.6 (2.34)*37.2 (2.34)59.3 (2.37)
 β2-microglobulin78.5 (1.32)**,****78.9 (1.32)**73.5 (1.32)80.6 (1.33)
 Creatinine73.5 (1.45)73.2 (1.45)71.7 (1.45)73.7 (1.45)
 Phosphate52.8 (2.13)48.8 (2.13)48.4 (2.13)51.0 (2.13)
 Urea80.7 (1.33)*****80.3 (1.33)****79.4 (1.33)81.6 (1.33)

LS mean +/- standard error

Comparisons are based on a mixed model with fixed effects of period and study dialyzer type, and the random effect of subject.

*P < 0.001 versus HD and HDF; **P < 0.001 versus HD; ***P < 0.01 versus HDF; ****P < 0.05 versus HDF; *****P < 0.05 versus HD.

doi: 10.1093/ndt/gfaa322

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