SP386
MEDITERRANEAN DIET AND MORTALITY ΙΝ CHRONIC KIDNEY DISEASE (CKD) STAGE 5D (DIALYSIS) PATIENTS Free

INTRODUCTION: Aims. To explore the association of adherence to a Mediterranean-style diet (MD) with all-cause mortality in stage 5D CKD patients

METHODS: 129 patients stage 5D CKD (66 on hemodialysis and 63 on peritoneal dialysis) (78 men and 51 women) with a mean age of 62±15 years were studied. A MD adherence score (MDS) (range 0-55, 55 representing maximal adherence) was estimated according to a previously reported method (Panagiotakos et al 2007). After completion of baseline assessment, patients were followed up for all-cause mortality. MDS dichotomized into 2 groups: patients belonging to the lower tertiles (Low MDS≤26 ) and the higher tertile (High MDS>26) of the baseline MDS distribution, respectively

RESULTS: During a median follow-up period of 20 months, 17 (13.1%) deaths occurred. Sixteen (17.8% ) patients died in the Low MDS group (n=90) and 1 (2.5%) patient in the High MDS group (n=39). Patients in the High MDS group had a lower risk of all-cause mortality ( {crude hazard ratio: 0.13 [95% confidence interval (CI), 0.02-0.99] }. This association was resistant to adjustment for univariate significant predictors of all-cause mortality: age, cardiovascular disease, serum albumin and malnutrition-inflammation score (adjusted HR: 0.12 (95% CI, 0.01-0.96). In a multivariate Cox regression model, where MDS entered as a continuous variable, after adjustment for all factors mentioned above, each 1-point greater MDS was associated with α 17% (OR= 0.83, 95% CI: 0.70-0.98) reduction of death of any cause.

CONCLUSIONS: Our results show an inverse association between MDS and all-cause mortality. Thus, greater adherence to a MD may improve clinical outcomes in stage 5D CKD patients.