SP396
LEPTIN AND NUTRITIONAL MARKERS IN HEMODIALYSIS PATIENTS

INTRODUCTION AND AIMS: Leptin is an adipokine and anorexigenic hormone, which also seems to have a pro-atherogenic effect and to participate in the development of hypertension, of oxidative stress and of endothelial dysfunction. Measuring and control of leptin-related factors may thus influence cardiovascular pathology in HD patients. Current data on factors related to serum leptin levels in chronic HD are inconsistent. Aim: to evaluate leptin levels in HD patients.

METHODS: We conducted a cross-sectional study that included 88 HD patients, with a mean age of 61.1±13.5 years, 20% of them being diabetic. We evaluated how leptin correlates with markers of inflammation, nutrition, dyslipidemia and other markers. We subsequently determined the strongest predictor for the leptin levels.

RESULTS: Levels of leptin were correlated with age (r=0.21 p=0.049), nutritional markers like body mass index (r=0.70, p<0.001), abdominal circumference (r=0.50 p<0.001), fat tissue mass (r=0.69 p<0,001) and lean tissue mass (r= -0.35 p<0.001), dyslipidemia markers like total cholesterol (r=0.27 p=0.01), LDL-cholesterol (r=0.22 p=0.04) and triglycerides (r = 0.23 p=0.03) and inflammatory markers like CRP (r=0.28 p=0.01), WBC (r=0.25 p=0.02) and with iPTH (r= -0.22 p=0.02). Body mass index was the most significant predictor of leptin levels in the multivariate linear regression analysis (p=0.009).

CONCLUSIONS: In our HD patients leptin correlates with nutritional and inflammatory markers, with the strongest predictor of leptin levels being body mass index. Acknowledgement: This project is supported by a grant of the Romanian National Authority for Scientific Research CNCSIS - UEFISCDI, project number PN- II- RU-TE-2014-4-1819.