INTRODUCTION AND AIMS: Patients with CKD are prescribed large amount of medications and adherence one of the major concerns in chronic disorders.Aim: To evaluate compliance for most common groups of medications in patient with chronic kidney disorders.We conducted prospective questionnaire based study of 167 adult patients suffering from CKD I-V from six months or more (GFR 43±12,2 ml/min by CKD-EPI formula); patients were included irrespectively of CKD reason (primary and secondary glomerulonephrities, diabetes, gout). Inclusion criteria: medications for CKD treatment were prescribed >3 month ago. Exclusion criteria: current dialysis and transplantation status.
METHODS: Materials and methods. 70 men and 97 women were examined in the study, mean age of respondents was 47,7 ±16,1 years. Patients got 2,6±0,8 medication in average. To get information about adherence to medications doctor - designed Morisky medication adherence questionnaire (MMAQ) was used to calculate overall adherence; opened medication adherence questionnaire was used to get information about adherence to glucocorticosteroids, cytostatics, antihypertensives, diuretics. Values are expressed as counts and percentage. Spearmann correlation test was used to find correlation among adherence, age, gender, number of medicines.
RESULTS: Results. 45% of patients had low and 29% high adherence. 93 of them get steroids (50% of them more than 1 year) and had compliance in 85%. 50 patients was treated by cytostatics with 80% adherence. 63% of patients got hypotensive medications and they showed high compliance - 93%. Diuretics were prescribed in 46 of them and 76% showed adherence for medication. Futher analysis showed, that in case of monotherapy (mainly hypotensive medications in CKD) adherence for medications was low in 67% of cases; median and high compliance was find in case of treatment of 2 and 3 medications. Nobody showed high compliance in case of 4 component treatment. Correlation analysis didn’t support relation with CKD stage, GFR, anemia and hypertension severity.
CONCLUSIONS: In group of CKD patients highest adherence was shown in hypertension treatment medications, but not in case of monotherapy; in case of polycomponent treatment highest compliance was defined in case of 2-3, but not one or four medications.
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