FP347
ATTRIBUTABLE RISK OF CHRONIC KIDNEY DISEASE ON MORTALITY IN A COMMUNITY-BASED POPULATION

INTRODUCTION AND AIMS: Chronic kidney disease (CKD) is a worldwide public health problem. We examined the effects of CKD and lifestyle-related diseases on all-cause and cardiovascular death in the Japanese community-based population.

METHODS: We used the database of 16,368 subjects (47% male, average 64 years) who participated in local health checkup from 2004 to 2015, and calculated the population attributable risk percent of hypertension, diabetes, smoking, CKD (albuminuria and/or estimated GFR <60 mL/min/1.73m2), each CKD component on all-cause and cardiovascular mortality, after the adjustment with background factors (age, gender, body mass index, alcohol consumption, dyslipidemia).

RESULTS: The prevalence of each disease at the time of enrollment was 46.2% for hypertension, 10.7% for diabetes, 17.6% for smoking, 16.9% for CKD, 8.0% for renal insufficiency (eGFR <60 mL/min/1.73m2), 10.6% for albuminuria (>30 mg/gCr), and 2.9% for proteinuria (>1+), respectively. The number of total deaths and cardiovascular deaths in the follow-up period (median 4.4 years) were 537 (3.3%) and 151 (0.9%). The adjusted population attributable risk percent on all-cause mortality is 3.8% for hypertension, 2.5% for diabetes, 6.5% for smoking, 6.0% for CKD, and 2.0% for renal insufficiency, 3.5% for albuminuria, and 1.4% for proteinuria, respectively. The adjusted population attributable risk percent on cardiovascular mortality is 13.9% for hypertension, 2.4% for diabetes, 8.9% for smoking, 7.7% for CKD, 3.2% for renal insufficiency, 4.9% for albuminuria, and 1.1% for proteinuria, respectively. In subgroup analysis, the influence of CKD was stronger in elderly and subjects with hypertension, diabetes and alcohol consumption.

CONCLUSIONS: This study showed that CKD commonly occur in the community-based population, and that the effect of CKD on all-cause and cardiovascular death is equal to or greater than lifestyle-related diseases.