INTRODUCTION AND AIMS: End-stage renal disease (ESRD) develops in up to 20% of patients with systemic lupus erythematosus (SLE). The long-term prognosis of renal transplant recipients with SLE is still controversial.Aim: Evaluate kidney transplantation outcomes for patients with SLE at a single center.
METHODS: We retrospectively studied all SLE patients who received a kidney allograft in our center between july 2005 and 2016. For comparative purposes a control group (No-SLE) was selected, matched for recipient age, female recipient, living donor, retransplant, year of transplant and peak PRA ≥5%. Patient and allograft outcomes were compared between cases and controls.
RESULTS: There were 1190 kidney transplants performed between july 2005-2016, including 17 in SLE patients [mean age 42.6 (31-51) years]. Mean follow-up after renal transplantation was 4.3 (1.4-7.6) years.In table 1 characteristics and outcomes in SLE and No-SLE kidney recipients are presented. From the Cox analysis performed, SLE was the single independent predictor of graft failure (HR=8.93; P=0.041). Early graft loss (<1 month after transplantation) was observed in 6 (35,3%) SLE patients, 5 due to intravascular thrombotic events and 1 due to a not functioning kidney. Late graft loss occurred in 1 SLE patient due to chronic rejection. SLE was significantly associated with shortened kidney graft survival, with 43.4 % of SLE grafts failing at 5 years, in contrast with only 5.9 % No-SLE.
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