SP527
WHAT ARE THE RELATIONSHIPS BETWEEN PERITONEAL SOLUTE TRANSPORT & PERITONEAL REABSORPTION IN 8-HOUR PROLONGED PERITONEAL EQUILIBRATION TEST

INTRODUCTION AND AIMS: The patients with high peritoneal solute transport show low ultrafiltration and high peritoneal reabsorption. However the relationships between solute transport and peritoneal reabsorption have been scarcely studied. The aim of the study was to correlate the solute transport parameters and the Peritoneal Reabsorption rates (PRr) obtained by means of the effluent volume differences between the 4^th and 8^th hour of a prolonged Peritoneal Equilibration Test (PET) using three different glucose solutions.

METHODS: Thirty-two peritoneal dialysis patients were randomly studied with three prolonged eight-hour PET (G-1.36%, G-2.27%, and G-3.86%) in less than one month. The peritoneal dialysate was voided and reinfused at 60’ and 240’ and then voided at 480’. Mass transfer area coefficients (MTAC), clearances of large solutes, small-pore ultrafiltration, and free water transport were calculated.

RESULTS: The PRr did not show significant differences within patients using any of three glucose solutions. Good or strong correlations were found between PRr and the solute transport parameters (r= 0.361, p=0.042 to 0.754, p=0.001). Then patients with high peritoneal reabsorption (High tertile: PRr higher than 1.50 mL/min) showed high solute transport parameters compared with those of low reabsorption rates (Low and middle tertiles: PRr lower than 1.50 mL/min) as shown with 1.36% glucose solution: Table 1Similar results were obtained with 2.27% and 3.86% glucose solutions. Middle and large molecule clearances (β-2-microglobulin, Albumin, total protein and Ig-G) showed also significant correlations (r=0.373, p=0.035 - 0.809, p=0.001) and the clearances of low versus high PRr displayed as well significant differences (p= 0.027 - 0.007).

CONCLUSIONS: In summary, the peritoneal reabsorption rates calculated as the effluent volume difference between the 4^th and 8^th hour of a Peritoneal Equilibration test, have moderate-to -strong correlations with solute transport parameters. Patients with high solute transport showed high peritoneal reabsorption rates.