SP034
THE RELATIONSHIP BETWEEN RENAL VOLUME AND THE INTRARENAL RENIN-ANGIOTENSIN SYSTEM ACTIVITY IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PATIENTS

Introduction and Aims: Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary renal disorder characterised by progressive renal cyst formation and kidney enlargement leading to end stage renal disease. Several studies have shown increased activity of the renin-angiotensin system (RAS) in patients with PKD, recently, involvement of the intrarenal RAS has been postulated. The purpose of this study is to examine the participation of intrarenal RAS and to evaluate the association with renal volume, renal function, and other clinical parameters in ADPKD patients.

Methods: Data were collected from 184 ADPKD patients. Plasma soluble (pro) renin receptor (s(P)RR) and urinary angiotensinogen (AGT) as the biomarker of intrarenal RAS status were measured by ELISA. We examined the urinary protein, estimated glomerular filtration rate (eGFR) , BUN, systolic blood pressure, height-adjusted total kidney volume (htTKV), ΔTKV, and cyst growth rate.

Results: s(P)RR was negatively correlated with eGFR (r = 0.45, P < 0.01) and positively correlated with htTKV (r = 0.32, P < 0.01) ,urinary protein (r = 0.30, P < 0.01), BUN (r = 0.32, P < 0.01), and systolic blood pressure (r = 0.34, P < 0.01). Urinary AGT/Cr was negatively correlated with eGFR (r = 0.48, P < 0.01) and positively correlated with ΔTKV (r = 0.68, P < 0.01), cyst growth rate (r = 0.63, P < 0.01), and BUN (r = 0.70, P < 0.01).

Conclusions: These results suggested that s(P)RR is involved in renal damage and cyst growth in ADPKD, particularly urinary AGT/Cr may have a role of the biomarker of relatively progressive cyst growth in ADPKD patients.