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Nikolina Basic-Jukic, Marijana Gulin, Tvrtko Hudolin, Marijana Coric, Zeljko Kastelan, Lea Katalinic, Vanja Ivkovic, Bojan Jelaković, MP705
EXPRESSION OF BMP-2 IN VASCULAR ENDOTHELIAL CELLS OF RECIPIENT MAY PREDICT DELAYED GRAFT FUNCTION AFTER RENAL TRANSPLANTATION, Nephrology Dialysis Transplantation, Volume 31, Issue suppl_1, May 2016, Page i574, https://doi.org/10.1093/ndt/gfw200.29Close - Share Icon Share
Introduction and Aims: Delayed graft function (DGF) is associated with increased incidence of acute rejections, decreased graft survival and prolonged hospitalizations. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF.
Methods: Seventy-nine patients undergoing renal transplantation from which epigastric artery samples were taken at the time of surgery, were included in this prospective study. According to the need for dialysis more than 7 days after transplantation, patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in media (BMP2m) and endothel (BMP2e) of epigastric artery was assessed by immunohistochemistry. Control group included 16 non-diabetic patients, nephrectomized due to localized renal cancer.
Results: DGF group patients had longer hospitalization, worse graft function at one year after transplantation and lower 1-year death censored graft survival compared to IGF group. Lower intensity of BMP2e staining was recorded in DGF compared to IGF and control patients. In DGF patients, 93% had no expression of BMP2e and 7% had 1st grade expression, compared to 45% and 41% in IGF group, respectively (χ2 = 11.3, P=0.001 for no expression and χ2 = 6.23, P=0.013 for 1st grade expression), and 31% and 50% in control group, respectively (χ2 = 12.6, P<0.001 for no expression and χ2 = 7.06, PFisher = 0.015 for 1st grade expression). Statistically significant difference in BMP2m expression between DGF, IGF and control group was not found, although lower expression in DGF group compared to IGF and control group was also indicated.
Conclusions: In conclusion, this study provides the first evidence that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.
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