Introduction and Aims: The assessment of the risks of kidney donation has tremendous social, ethical, economical and clinical implications, in particular in Countries in which living donation is the predominant kidney transplantation; hence the controversy on considering kidney donors as CKD patients. Recent data suggest a higher risk for Preeclampsia in female donors.
Methods: Analysis of patients with a single kidney in a large multicentric cohort of pregnant CKD patients, gathering 731 pregnant patients with CKD (in 2000-2013); 53/731 had a single kidney (anatomical or functional). The data of CKD stage 1 with single kidney were discussed with respect to 835 low-risk pregnancies gathered in the same Centers in the same period.
Results: Single kidneys accounted for 7% of the overall referred CKD patients; 29 were singleton deliveries in CKD stage 1 women with anatomical or functional single kidney (on overall 265 CKD stage 1 pregnancies). Considering only CKD stage 1, pregnancy outcomes differed significantly from the control low-risk pregnancies, with significantly higher risk for pre-term delivery in mothers with a single kidney (Odds ratio: 8.091 (3.576-18.305); (table).
Conclusions: Our data support considering women with single kidney at risk for adverse pregnancy outcomes and in particular of preterm delivery.
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