-
Views
-
Cite
Cite
Hiroyuki Terawaki, Hirofumi Nakano, Fumihiro Takeguchi, Toshio Hasegawa, Masaaki Nakayama, Masao Okazaki, Tatsuo Hosoya, Regression of parathyroid gland swelling by treatment with cinacalcet, Nephrology Dialysis Transplantation, Volume 24, Issue 2, February 2009, Pages 690–691, https://doi.org/10.1093/ndt/gfn579
- Share Icon Share
Extract
Sir,
Calcimimetic compounds, such as cinacalcet, reduce parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism, as Fukagawa et al . demonstrated in the recent NDT article [ 1 ]. However, whether calcimimetic compound can reduce the size of an already-swollen parathyroid gland (PTG) is unclear. Here we report our observations of changes in the PTG size in a single case of secondary hyperparathyroidism treated with cinacalcet.
The patient was a 59-year-old woman who had been receiving haemodialyis since December 2003 for nondiabetic end-stage renal failure. In December 2006, elevated levels of serum intact PTH and alkaline phosphatase (ALP) were found (Table 1 ). Ultrasound examination revealed swelling of the right upper, right lower and left upper lobes of the PTG. Intravenous administration of the vitamin D analogue maxacalcitol (Oxarol®, Chugai Pharmaceutical Co., Ltd, Tokyo, Japan) reduced the levels of both intact PTH and ALP; however, the PTG (especially the left upper lobe) gradually enlarged, and the product of the serum levels of calcium and inorganic phosphorus (Ca × Pi) reached 100 mg 2 /dL 2 .
Comments