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Ismail Islek, Tuncer Degim, Cemal Akay, Ali Türkay, Tekin Akpolat, Charcoal haemoperfusion in a child with amitriptyline poisoning, Nephrology Dialysis Transplantation, Volume 19, Issue 12, December 2004, Pages 3190–3191, https://doi.org/10.1093/ndt/gfh232
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1Department of Pediatrics and 2Department of Nephrology, Ondokuz Mayis University, School of Medicine, Samsun, Turkey, 3Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey and 4Department of Toxicology, Gülhane Military Medical School, Ankara, Turkey
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Tricyclic antidepressant (TCA) overdose is a relatively common cause of poisoning. According to the American Association of Poison Control Centers, 7961 patients with amitriptyline poisoning were reported in 2000. Of these, 958 were under 6 years old, 6388 needed treatment in a health care facility and 68 patients died [1]. The current therapy of TCA overdose includes preventive measures such as gastric lavage, activated charcoal, anticonvulsants, vasopressors for hypotension, and sodium bicarbonate infusion for dysrhythmias [2,3]. Although charcoal haemoperfusion (CHP) has been used in the management of amitriptyline overdose, the data regarding CHP in the management of amitriptyline overdose is controversial [3–5]. To our knowledge, there is no report related to the use of CHP in children with amitriptyline poisoning in the English literature. Here, we report a child with amitriptyline poisoning who showed dramatic improvement after CHP treatment.
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