Extract

(Section Editor: M. G. Zeier)

Case

A 49‐year‐old Caucasian female underwent a cadaveric renal transplantation in June 1999 because of end‐stage renal failure secondary to autosomal dominant polycystic kidney disease, for which she had been treated with chronic haemodialysis since April 1996. Her medical history was otherwise unremarkable. She had never required substitution therapy with erythropoietin. No induction therapy was administered before transplantation. During the transplantation procedure the left native kidney was removed in order to make space for the transplant. The post‐transplantation recovery was uneventful and she was discharged on day 14 with a haemoglobin of 9.2 g/dl and a serum creatinine of 1.94 mg/dl. The daily immunosuppressive regimen consisted of methylprednisolone 12 mg, tacrolimus 12 mg and mycophenolate mofetil 1000 mg twice daily. Serum tacrolimus levels were kept between 12 and 15 μg/l. Other medications included trimethoprim/sulfamethoxazole 800/160 mg and cimetidine 400 mg. Since the donor's serologic status was positive for cytomegalovirus (CMV), ganciclovir in an oral dose of 1000 mg daily was administered as a standard prophylactic measure.

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