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Isidro B. Salusky, William G. Goodman, Managing phosphate retention: is a change necessary?, Nephrology Dialysis Transplantation, Volume 15, Issue 11, November 2000, Pages 1738–1742, https://doi.org/10.1093/ndt/15.11.1738
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Editor's note Please see also Letter to the Editor by F. Eifinger et al. pp. 1892–1894.
Introduction
Cardiovascular disease accounts for half the deaths in adults treated with maintenance dialysis, and mortality from cardiovascular causes is far higher than that in the general population [1,2]. Contributing factors include sodium and water overload, hypertension, diabetes mellitus, alterations in lipid metabolism and elevated levels of homocysteine in serum [3–8]. Despite considerable progress over the last two decades in the management of these and other traditional cardiovascular risks, the mortality rate from cardiovascular causes has not diminished in patients with end‐stage renal disease (ESRD) [9]. Indeed, cardiovascular mortality for those treated with dialysis continues to far exceed that predicted from the combined risks attributable to age, sex, systolic blood pressure, left ventricular hypertrophy, serum total and HDL cholesterol, cigarette smoking and diabetes mellitus [10]. Other factors are likely, therefore, to account for the high incidence of cardiovascular death in those undergoing long‐term dialysis.
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