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Ali Arıcan, Namık Özbek, Volkan Baltacı, Mehmet Haberal, Philadelphia chromosome (+) T-cell acute lymphoblastic leukaemia after renal transplantation, Nephrology Dialysis Transplantation, Volume 14, Issue 8, August 1999, Pages 2054–2055, https://doi.org/10.1093/ndt/14.8.2054
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Sir,
Post-transplant lymphoproliferative disorders (PTLD) is a well- known complication of immunosupressive treatment after solid organ transplantation [1]. The majority of PTLD are of B-cell origin and associated with Epstein-Barr virus (EBV) infection [2]. T-cell variants of PTLD are much less common and not well characterized. They exhibit heterogeneous clinical, morphological and phenotypical characteristics and EBV does not appear to be involved in their pathogenesis [3]. Although cases with acute myeloblastic leukaemia, chronic myelocytic leukaemia, and adult T-cell leukaemia/lymphoma following renal transplantation have been reported frequently, there are a few cases with acute lymphoblastic leukaemia (ALL) in the literature [4–7]. In this report, we described a patient who developed Philadelphia (Ph) (+) T-cell ALL after renal transplantation.
The patient, a 50-year-old male, was weak, complained of pain in the right upper abdominal quadrant and was producing dark urine at the time of admission. He had a history of chronic renal failure requiring haemodialysis at the age 45. Five months after beginning dialysis, he underwent a living-related renal transplantation, receiving a kidney from his daughter and immunosuppressive agents including prednisolone, azathioprine and cyclosporine-A were started. Three months before the last admission he was operated because of acute cholecystitis. In that time, pancytopenia and eosinophilia were observed on peripheral smear, however, bone marrow aspirates and biopsy were normal. The haematological findings returned to normal and the patient was discharged a month after this surgery.
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