-
Views
-
Cite
Cite
Jan Broekroelofs, Coen A. Stegeman, Gerjan Navis, Paul E. de Jong, Prevention of renal function loss after non-renal solid organ transplantation—how can nephrologists help to keep the kidneys out of the line of fire?, Nephrology Dialysis Transplantation, Volume 14, Issue 8, August 1999, Pages 1841–1843, https://doi.org/10.1093/ndt/14.8.1841
Close - Share Icon Share
Extract
After solid organ transplantation, be it renal or non-renal, renal function loss is common [1–4]. In renal transplantation, chronic renal function deterioration as an important cause of long-term graft loss is well recognized [1]. In this population, studies aimed at elucidating its mechanisms and improving long-term renal allograft prognosis are performed. Whereas in recipients after non-renal solid organ transplantation progressive renal function loss is an important problem as well, the knowledge on renal morbidity in these populations is relatively limited and scattered. Improvements in non-renal solid organ transplantation have led to improved patient and graft survival. The burden of renal morbidity in these populations grows by the increasing number of recipients, and by the increasing number surviving long enough to develop clinically significant renal problems. Therefore, it becomes mandatory to develop renoprotective strategies in these high-risk groups. As failing kidneys after non-renal organ transplantation share many features, such as vascular obliteration with ischaemic glomerular collapse and sclerosis, tubular atrophy, and interstitial fibrosis with chronic renal transplant failure [5], insights derived from renal transplantation may be useful in this respect [1]. However, subtle differences have been found at the matrix protein level between kidneys after renal as compared to non-renal transplantation, pointing to differences in pathogenic mechanisms as well [6]. Clearly, insights derived from renal transplantation need to be combined with knowledge on specific risk factors for each particular population of non-renal transplant recipients. The other way round, insights from renal function loss in non-renal transplant recipients may increase our understanding of non-immunological factors in chronic renal transplant failure.
Comments