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Fumitaka Shimizu, Masataka Taguri, Yoshiko Harada, Yutaka Matsuyama, Kazuhiro Sase, Makoto Fujime, Impact of Dry Ejaculation Caused by Highly Selective α1A-blocker: Randomized, Double-blind, Placebo-controlled Crossover Pilot Study in Healthy Volunteer Men, The Journal of Sexual Medicine, Volume 7, Issue 3, March 2010, Pages 1277–1283, https://doi.org/10.1111/j.1743-6109.2009.01663.x
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ABSTRACT
Dry ejaculation with loss of seminal emission is reported in patients who have been administered silodosin, an alpha1A-adrenoceptor antagonist.
We investigated the impact of dry ejaculation caused by orally administered silodosin on orgasmic function.
In a double-blind crossover study, 50 healthy volunteer men were randomly assigned to receive either a single dose of 4-mg silodosin or placebo with 3 days of washout before crossover. Subjects masturbated 4 hours after administering agents.
Numerical rating scale (NRS) score from 0 (highest) to 10 (lowest) for subjective quality of orgasm, the subjective number of contractions of the bulbocavernosus/pelvic floor muscles, and the amount of semen were examined.
After the administration of silodosin, the NRS score worsened by 1.3 points (P = 0.003), the number of contractions of the bulbocavernosus/pelvic floor muscles decreased by about 1 (P = 0.003), and there was a decrease of 1.8 mL in the amount of semen produced (P <0.0001). Eleven men overall (22%) on silodosin administration had less than a 50% decrease from baseline in the amount of semen.
Silodosin may adversely affect the subjective orgasmic function by causing an abnormal ejaculation with decreased (or no) semen discharge and a decrease in the number of bulbocavernosus/pelvic floor muscle contractions. Semen passing through the urethra and sufficient rhythmic contraction of the muscle of the pelvic floor may contribute to the subjective pleasure of orgasm.
