LONG-TERM CLINICAL MANAGEMENT AND OUTCOMES OF CHILDREN WITH SMALL GENITALIA

Small genitalia in children can be a source of significant concern for both patients and caregivers, often prompting evaluation for underlying endocrinological or anatomical conditions. Various treatment approaches have been explored to address this issue, including hormone therapy and topical treatments aimed at stimulating growth. This study evaluates the safety and efficacy of different therapeutic interventions we use, including hormonal injections, topical testosterone creams, and alternative treatments for managing small genitalia in pediatric patients over a multi-year follow-up period.

Children diagnosed with small genitalia were included. Patients were divided into groups based on their treatment regimen, which included Choriomon 5000 IM injections, Testosteron 5% cream, and other medications such as Minirin. Follow-up visits were conducted regularly, with outcomes assessed via penile measurements, doppler ultrasound findings, and hormonal profiles (eg, LH, FSH). Adverse events were monitored, and the efficacy of each intervention was compared based on longitudinal changes in genital size and hormonal markers.

All treatment groups exhibited improvements in penile and testticular size along with hormonal parameters, with significant growth noted in patients receiving testosterone-based therapy. Side effects were minimal, with mild pain and bruising reported in a small number of patients undergoing injections. Discontinuity in treatment adherence, often due to caregiver preference or patient tolerance, was noted, which influenced long-term outcomes. Final analysis and results will be presented during the conference.

Hormonal and topical treatments are effective and safe interventions for managing small genitalia in children. The findings suggest that early intervention, continuous follow-up, and patient adherence to treatment protocols are key to achieving optimal outcomes. Further studies are required to compare long-term efficacy across different therapeutic approaches and to explore the psychological impact on affected children.

None.