(257) CYSTOSCOPY AND ITS POTENTIAL ASSOCIATION WITH PEYRONIE’S DISEASE: A RETROSPECTIVE COHORT STUDY

Patients may present with Peyronie's disease (PD) following cystoscopy. The potential link between the two remains uncertain. We aimed to investigate the potential association.

We retrospectively analyzed electronic health records from the Capital and Zealand regions of Denmark to study men diagnosed with PD between January 2018 and October 2022. Initially, we identified men diagnosed with PD between January 2018 and October 2022 and calculated their interquartile age range. We then focused on men who underwent cystoscopy within the same time frame and whose age fell within the same interquartile range (IQR). We collected data on PD risk factors (diabetes, hypertension, ischemic heart disease, erectile dysfunction, Dupuytren’s contracture) and determined the number of men diagnosed with PD within a year after their cystoscopy. We included similar-aged men who had scrotal ultrasound or thoracic x-ray for comparison, representing urological and non-urological examinations.

The IQR for PD patients was 52-66 years. During the timeframe, 6,210 men within this age range underwent cystoscopies, 6,691 underwent scrotal ultrasound, and 70,927 underwent thoracic x-ray. Risk factors for PD were present in 23% in the cystoscopy group, 17% of the ultrasound group, and 22% in the x-ray group. Within the following year of their respective procedures, PD were diagnosed in 0.97%, 1.85%, and 0.16% in the three groups, respectively. The adjusted odds ratios for PD were 0.369 (95% CI 0.268 – 0.507, p <0.0001) for cystoscopy vs. ultrasound and 6.258 (95% CI 4.547 – 8.612, p <0.0001) for cystoscopy vs. x-ray.

As there is no plausible mechanism for scrotal ultrasound to cause PD, our analysis implies that having an examination of the male genitals leads to a higher chance of being diagnosed with PD, while cystoscopy is not a specific risk factor. Prospective studies are needed to further address the topic.

No conflict of interests.