Extract

The androgen receptor (AR) plays a critical role in mediating the effects of testosterone on sexual development, libido, and sexual functions in men and women. Herewith is an overview and opinion on the role of the AR and the CAG repeat polymorphism with the AR gene in the area of sexual desire, libido, and erectile function, highlighting clinical aspects. Additionally, potential implications are discussed in terms of the CAG repeat polymorphism on sexual health and future directions for research in this area.

Androgens, particularly testosterone, play a crucial role in regulating sexual desire, libido, and sexual function. The AR is a nuclear hormone receptor that is expressed in various tissues, including the brain, reproductive organs, and skeletal muscle. It functions as a transcription factor, modulating the expression of target genes in response to androgen binding. The AR mediates these effects by interacting with androgen response elements in the DNA and regulating the transcription of genes involved in sexual development and function.1

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