-
Views
-
Cite
Cite
W.-J. Bae, K.-W. Lee, S.-W. Yim, H.-J. Cho, U. Ha, S.-H. Hong, J.-Y. Lee, S.-W. Kim, PO-01-009 Electric Stimulation Hyperthermia Relieves Inflammation through Inhibiting TLR4 Signal Transduction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome, The Journal of Sexual Medicine, Volume 16, Issue Supplement_2, May 2019, Page S51, https://doi.org/10.1016/j.jsxm.2019.03.173
- Share Icon Share
Extract
Objective
The chronic prostatitis (CP), including chronic pelvic pain syndrome (CPPS), is the most commonly prostatitis case, which is a highly prevalent syndrome with significant decreased quality of life. However, there are insufficient data supporting the use of devices, and the exact mechanism has not been determined so far. The aim of this study was to evaluate the effect of electric stimulation (ES) on CP/CPPS and explore the mechanism.
Methods
RWPE-2 cells randomly divided into 4 groups: 1) sham control group, 2) lipopolysaccharide (LPS) inducing inflammation group, 3) ES treated (frequency without heat) group, and 4) ES treated (frequency with heat) group. Cells in inflammation and treatment groups were stimulated by LPS inducing inflammation. Sprague-Dawley rats (n=40) were randomly divided into 4 groups: 1) normal control group, 2) prostatitis group, 3) ES treated (frequency without heat) group, and 4) ES treated (frequency with heat) group. Prostatitis were induced by 17 beta-estradiol and dihydrotestosterone for 4 weeks.