Extract

Objective

Platelet-rich plasma (PRP) demonstrated its safety and effectiveness as monotherapy for erectile dysfunction (ED), as well as low-intensity extracorporeal shockwave therapy (LI-ESWT). The purpose of the present study was to evaluate safety and effectiveness of their combined use for treating ED. We hypothesized that angiogenic, neuroprotective and neurogenic effects of PRP could be enhanced by the LI-ESWT.

Methods

10 men, mean age of 44.25 (22-69), experiencing ED symptoms for 2.95 years, were included into the study for 60 days. Patients were treated with 6 rounds of intracavernous PRP injections activated with 10% CaCl2 solution and 12 LI-ESWT procedures during 6 weeks. Each PRP injection was performed in middle and distal corpus cavernosum parts bilaterally. 2000 waves were applied at every LI-ESWT procedure to each cavernous body. Effects of combined therapy were assessed by validated questionnaires (IIEF-5, SEP, GAQ) and penile duplex Doppler ultrasound (PDDU) with intracavernous PgE1 injection.

Results

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