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Z. Zhang, C. Zhou, Y. Xu, B. Shi, HP-03-001 The Effect of Dapoxetine in the Treatment of Chronic Prostatitis Combined with Premature Ejaculation, The Journal of Sexual Medicine, Volume 16, Issue Supplement_2, May 2019, Pages S34–S35, https://doi.org/10.1016/j.jsxm.2019.03.128
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Objective
To determine the effect of dapoxetine in the treatment of PE combined with chronic prostatitis.
Methods
A total of 190 outpatients with acquired PE combined with chronic prostatitis were employed in this study. They were randomly divided into the control group (n=95) and experimental group (n=95). The control group received conventional therapy including α-receptor blocker and antibiotics. The experimental group was given conventional therapy combined with dapoxetine. The Premature Ejaculation Diagnostic Tool (PEDT) and the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI)were performed before and 2/4 weeks after treatment to evaluate the symptoms and treatment outcomes.
Results
Before treatment, no significant difference of PEDT and NIH-CPSI scores was found between the two groups. There are no significant correlation between the scores by spearman‘s correlation(r=0.145,P=0.061) .After 2 weeks treatment, PEDT and NIH-CPSI scores were all improved in experimental group(P<0.001).In the control group, NIH-CPSI scores were improved (P=0.037), but PEDT scores were not improved(P=1.101).While no difference of the PEDT and NIH-CPSI scores were detected between the two groups(P=0.22 and P=0.60 respectively ). After 4 weeks treatment, PEDT and NIH-CPSI scores were still improved in experimental group (P<0.001). Moreover, PEDT and NIH-CPSI scores were also improved in control group(P<0.001).Although no significant difference were found between the two groups (P=0.237),while the quality of life scores and PEDT scores showed a better improvement than control group (P<0.001).No severe side effects were found in this clinical trial.
