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Objective

Erectile dysfunction (ED) has been associated with a higher risk of developing cardiovascular diseases, metabolic disorders and other comorbidities. Patients surgically treated for renal cell carcinoma (RCC) are at risk of developing chronic kidney disease (CKD) over time. Detecting those at higher risk of CKD is crucial for an adequate treatment and follow-up planning. We tested the association between preoperative ED and the risk of developing CKD after surgery for RCC.

Methods

A total 106 male patients surgically treated for RCC at a single center, between 2012 and 2018, had available preoperative erectile function (EF) data. Preoperative EF was assessed with the International Index of Erectile Function-EF (IIEF-EF) tool. This questionnaire is routinely administered at our center to RCC patients aged ≤70 years. Patients were submitted to either partial (PN) or radical nephrectomy (RN) according to clinical stage. After surgery, they were routinely assessed every 6 months for the first 2 years and annually thereafter; estimated glomerular filtration rate (eGFR) was calculated by the CKD Epidemiology Collaboration formula (CKD-EPI). Patients missing follow-up data were excluded (N=16). Kaplan Meier analyses estimated the cumulative incidence of CKD (eGFR<60 ml/min). Cox regression analyses tested the association between preoperative EF and the risk of postoperative CKD.

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