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Republic of Korea Won-Ki Lee, H.-C. Jeong, K.-T. Ko, K.-H. Moon, D.-Y. Yang, PS-05-012 A Comparison of the Efficacy and Safety Between Hyaluronic Acid and Polylactic Acid Filler Injection in Penile Augmentation: A Multicentre, Patient/Evaluator-blinded, Randomised Controlled Trial, The Journal of Sexual Medicine, Volume 16, Issue Supplement_2, May 2019, Page S17, https://doi.org/10.1016/j.jsxm.2019.03.081
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Objective
The clinical utility of fillers has been extensively studied for the face, whereas studies for the penis are lacking. This study aimed to compare the efficacy and safety between hyaluronic acid (HA) and polylactic acid (PLA) filler injection for penile augmentation (PA) in randomised controlled trial.
Methods
72 patients with small penis syndrome from 3 institutions were enrolled between March and July 2016. The patients were divided into two groups: the HA group comprised 36 patients injected with HA and the PLA group, 36 patients injected with PLA. Penile girth and satisfaction were assessed at baseline and at 4, 12, 24, and 48 weeks after injection.
Results
Penile girth increases adequately lasted up to 48 weeks in both groups (16.95±10.53 and 13.49±9.98 mm of mean increase in the HA and PLA group, respectively, each P<0.001). The mean penile girth increase in the HA group was significantly greater than that in the PLA group at 4 weeks (P<0.001). Then, it gradually decreased and was no longer significantly different at 48 weeks (P=0.075). Satisfaction levels increased after injection and were maintained up to 48 weeks. There were no significant differences in overall satisfaction level increases between the groups (each P>0.05). Filler injection-related adverse events were mild and transient, and occurred in 1 and 3 patients in the HA and PLA group, respectively.