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H.-C. Jeong, K.-T. Ko, S.-Y. Kim, W.-K. Lee, D.-Y. Yang, S.-H. Lee, PS-05-010 Effects of Daily Tadalafil 5mg Administration on Post Micturition Dribbling (PMD) in Men with Lower Urinary Tract Symptoms: A Prospective, Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Study, The Journal of Sexual Medicine, Volume 16, Issue Supplement_2, May 2019, Page S17, https://doi.org/10.1016/j.jsxm.2019.03.079
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Objective
Although post-micturition dribbling (PMD) is a very uncomfortable symptom of lower urinary tract symptoms (LUTS) but it tends to be underestimated in the clinical field. It has a different pathophysiology than LUTS and its treatment is also different from the conventional one. As part of senile change, decreased volume of penile corpus cavernosum and associated dilation of the bulbous urethra occurs, these are thought to be associated with symptoms of PMD. So we investigated the effect of daily dosing of 5 mg tadalafil on PMD.
Methods
From Nov 2017 to Aug 2018, patients aged 20 to 70 years with IPSS score of 8 or higher and had PMD symptoms were included. In total, 102 patients were enrolled from 3 hospitals participated in this study. Eligible patients were randomly assigned to the tadalafil 5mg group or tadalafil placebo group. Primary endpoint was the changes in PMD symptoms that were evaluated through the “Hallym Post Micturition Dribbling Questionnaire (HPMDQ),” which was designed for this study. IPSS, IIEF, PEDT, PEP, IELT questionnaire were compared among groups at 4 and 12 weeks.