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S.-T. Ahn, S.-W. Kim, H.-A. Jang, J.-Y. Min, J.-J. Kim, D.-G. Moon, PS-03-005 The Efficacy of Vaginal Moisturizers Composed Β-glucans in Treatment of Vulvo-vaginal Atrophy with Post-menopausal Women, The Journal of Sexual Medicine, Volume 16, Issue Supplement_2, May 2019, Page S10, https://doi.org/10.1016/j.jsxm.2019.03.060
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Objective
To investigate the efficacy and safety of vaginal moisturizers which composed with natural β-glucans on vulvo-vaginal atrophy (VVA) related vaginal dryness.
Methods
The prospective crossover study was conducted. Twenty patients were randomized to 1 of 2 treatment sequences, application vaginal moisturizers type 1 (composed of 0.6 % β-glucan only)-type 2 (composed of 0.6% β-glucan and 0.6% hyaluronic acid) or type 1–type 3 (composed of 0.6% β-glucan and extracts from Sophora flavescens, Houttuynia Cordata Extract, Aloe barbadensis). Each types of vaginal moisturizers was given for 5 days, separated by a 1-week washout interval. Efficacy was assessed by the vaginal pH, vaginal swab culture and patient self-reporting of improvement of VVA related symptoms questionnaire.
Results
Ten patients were treated with type 1 and 2 vaginal moisturizers and 10 patients treated with type 1 and 3 vaginal moisturizers. Their mean aged was 58.1±5.9 (range: 51-77). All patients complaint vaginal dryness and other frequent symptoms followed as dyspareunia (15/20, 75%), vaginal itching (8/20, 40%) and four odor (6/20, 30%). After treatment with type 1 and 2 vaginal moisturizers a significant improvement in vaginal dryness (p<0.001, both), vaginal itching (p=0.031, both) and dyspareunia (p<0.01 and p=0.031) was reported by the patients. Although type 3 vaginal moisturizers were effect in vaginal dryness (p=0.002) and dyspareunia (p=0.002), 5 of ten patients were dropped out due to irritative burning sense after application. The vaginal pH was significantly decreased after type 1, type2 and type 3 vaginal moisturizers. (p<0.001, p=0.005 and p=0.007) Eight patients recovered Lactobacillus on vaginal culture after treatment with type 1 vaginal moisturizers.
