-
Views
-
Cite
Cite
Alisa J. Stephens-Shields, Christina Wang, Peter Preston, Peter J. Snyder, Ronald S. Swerdloff, Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials, The Journal of Sexual Medicine, Volume 16, Issue 7, July 2019, Pages 951–953, https://doi.org/10.1016/j.jsxm.2019.04.003
- Share Icon Share
Abstract
A recent study of older men participating in the Testosterone Trials (TTrials) defined a clinically meaningful change in the Psychosexual Daily Questionnaire (PDQ) question 4 in hypogonadal men age ≥65 years. This study defines clinically meaningful change in the same population for sexual desire assessed by PDQ question 1.
To determine a clinically meaningful change in the answers to question 1 of the PDQ in hypogonadal older men.
Participants in the Sexual Function Trial of the TTrials were randomly divided into a training and test set. Anchor-based methods, including regression analysis, receiver operating characteristic curves, and empirical cumulative distribution functions, were used to determine a clinically meaningful change on question 1 in the training set, and the selected threshold was evaluated in the test set for an effect of testosterone treatment.
A clinically meaningful increase in question 1 of the PDQ was determined to be ≥0.7 points.
Question 1 of the PDQ can be used to assess sexual desire in response to testosterone treatment.
Data were obtained from a single large study of older hypogonadal men.
Clinically meaningful improvement of sexual desire is a change of ≥0.7 in the score of question 1 of the PDQ.