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O. Romashchenko, I. Gorpynchenko, S. Melnykov, V. Biloholovska, N. Mironenko, M. Khodzhava, S. Koval, HP-07-005 Formation of Dyspareunia in Women with Surgical Menopause, The Journal of Sexual Medicine, Volume 14, Issue Supplement_4a, April 2017, Page e157, https://doi.org/10.1016/j.jsxm.2017.03.059
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Extract
Objective
Evaluation of frequency of dyspareunia in women with surgical menopause.
Methods
A sexological, gynaecological, and psychological examination of 37 women aged from 38 to 52 with surgical menopause was carried out: after hysterectomy with ovariectomy – 14 patients (I group), and after hysterectomy without overiectomy – 23 patients (II group). Sexological examination included: questionnaire through interview, assessment of vessel reactions of genitals (Doppler method of clitoris vessels using XARIO TOSHIBA machine, pH-test of vagina) before and after videoerotic stimulation, determination of estradiol levels (E2), total and free testosterone, sex hormone-binding globulins (SHBG), and free testosterone index (FT). Concentration of nitrite anion NO2 was determined in non-protein extracts of vaginal mucous with the help of Griess reagent using spectrophotometric method on photometer Screen Master. Content of whole protein in trials was determined by the method of Bradford M.M. (1976).
Results
Dyspareunia was formed after 1-2 years of surgical treatment in 85% of women of group I and in 52.2% of group II at the background of lubrication disorders, and atrophic changes from the side of urogenitals. In women with dyspareunia the speed of voluminous blood flow was 0.6-1.3 cm/s before sexual stimulation and the same after it at the background of reduction of E2 (1.7-2.1 times – in group I, in 1.3-1.9 times in group II) and levels of metabolites of nitric oxide in vaginal mucous (9.9±1.1 nmol/mg in group I, 12.3±2.5 nmol/mg in group II).