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Objective

To assess patients’ knowledge of the potential treatment-emergent adverse events (AEs) of alpha-blockers used for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) in the real-life setting.

Methods

A cohort of men treated with alpha-blockers for LUTS/BPH was invited to anonymously complete a 15-item questionnaire assessing the attention they had paid to the patient information leaflet before using any compound and what they had reminded in terms of potential AEs. Descriptive statistics was applied to describe the whole cohort.

Results

Complete data were available for 223 men [mean (SD) age: 59.7 (11.8) yrs; range 25-83]. Overall, 162 (72.6%) reported a stable sexual relationship. Educational status was primary/secondary school and high school/university degree in 41 (18.4%) and 176 (78.9%) patients, respectively. Of all, 175 (78.4%) reported that they typically read the information leaflet provided with any new medication. Of these, 114 (65.1%) reported to read the leaflet before starting every medication, whereas 61 (34.8%) after having started the treatment. More precisely, 167 (80.3%) men have read the information related to the potential AEs before starting the therapy with alpha-blockers (any type). Overall, 109 (48.9%) and 64 (28.7%) patients remembered ejaculatory disorders and hypotension/ other cardiovascular disorders, respectively. Reduced/absent orgasmic feeling, low sexual desire, and erectile dysfunction were also reported by 16 (7.2%), 68 (30.5%) and 39 (17.5%) patients, respectively. Both sexual and cardiovascular AEs were more frequently remembered by younger patients (all p≤0.03) and men with a higher educational status (all p≤0.005).

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