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F. Dimitriadis, A. Zachariou, S. Skouros, A. Chatzikonstantinou, P. Tsounapi, A. Takenaka, N. Sofikitis, PS-07-005 The Impact of Mirabegron on Erectile Function of Males with Overactive Bladder, The Journal of Sexual Medicine, Volume 14, Issue Supplement_4a, April 2017, Page e128, https://doi.org/10.1016/j.jsxm.2017.03.129
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Extract
Objective: The prevalence of erectile dysfunction (ED) is large in men with lower urinary tract symptoms (LUTS) including overactive bladder (OAB) (J Sex Med. 2008; 5: 2904-10). Recent studies in animals have shown that mirabegron, a β3-adrenoreceptor agonist, has positive effect on the male rat erectile function (Andrology, Suppl., pp 116-117, 2016). The aim of the current prospective study was to determine the effect of mirabegron, on the male erectile function.
Methods
Fifty two men suffering from OAB participated in this study and were divided into three groups. Group A (negative control group) included 17 patients who did not receive any treatment for a period of 16 weeks. Group B included 18 patients who received mirabegron (50 mg/daily) for 16 weeks for the OAB treatment. Group C (positive control group) included 17 patients who received L-carnitine (1g/daily) for 16 weeks. All patients were evaluated using the International Index of Erectile Function (IIEF-5) in the beginning and in the end of the sixteen-week-period. Urodynamic studies were conducted in the beginning and in the end of the observation period/clinical trial-period in all groups.