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K. Herkommer, J. Hallanzy, M. Kron, F.-M. Köhn, P. Albers, C. Arsov, M. Kuczyk, F. Imkamp, B.A. Hadaschik, M. Hohenfellner, J.E. Gschwend, PS-07-001 Prevalence of Erectile Dysfunction in 45-Year Old German Men in Association with Risk Factors and Comorbidities-Results of the German Male Sex-Study, The Journal of Sexual Medicine, Volume 14, Issue Supplement_4a, April 2017, Page e127, https://doi.org/10.1016/j.jsxm.2017.03.125
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Objective
We analyzed erectile dysfunction (ED) in a representative sample of 45-year old German men and assessed the association with lifestyle factors and ED-related comorbidities.
Methods
Data was collected within the German Male Sex-Study (part of the PROBASE prostate cancer screening trial) between May 2014 and April 2016. 45-year old men living in four German regions were invited within a screening trial. 10.135 Caucasian, heterosexual and sexually active men were included in this analysis. An anamnesis interview was obtained for all men including information on comorbidities and medication. Weight and waist circumference were measured on site. Erectile function was evaluated using the International Index of Erectile Function (IIEF-EF(6)). The presence of ED was defined as IIEF-EF-Score ≤25. Association of ED and comorbidities/lifestyle factors were analyzed by logistic regression.
Results
The prevalence of ED was 25.2% (IIEF-EF: 6-10:3.1%, 11-16:9.2%, 17-21:4.2%, 22-25:8.7%). We ascertained a baseline risk of 14.4% for men without ED-related comorbidities and with healthy lifestyle factors: no smoking, waist circumference <94cm, physical activity ≥4 days a week. ED-prevalence increases with the number of lifestyle factors (0 factors: 21.8%; 3 factors: 33.3%) and comorbidities (0 comorbidities: 22.4%; ≥3 comorbidities: 64.3%). In multiple logistic regression with backward elimination the following factors associated with ED were identified: Comorbidities: Depression [OR 1.87], lower urinary tract symptoms (defined as International Prostate Symptom Score >7) [OR 1.68], diabetes mellitus [OR 1.38], hypertension [OR 1.22]. Lifestyle factors: Poor general health status (first question of SF12) [1.72], waist circumference (≥102cm) [OR 1.31], physical activity (<2 days a week minimum 30 minutes per day mild exercise) [OR 1.27], smoking regularly [OR 1.15]. The only factor eliminated during variable selection was BMI even though this factor showed a crude OR of 1.42.
