Extract

Objective

Aim of the study is to examine the association of testosterone levels and subsequent fatal and non-fatal coronary events in men with erectile dysfunction (ED).

Methods

Total testosterone (TT) was measured in a prospective cohort of ED patients followed 6 years for the occurrence of fatal and non-fatal cardiac events. Proportional hazards regression models were used to evaluate the association of TT and coronary artery disease (CAD) risk.

Results

Among the 367 patients (57 y/o) at study entry, 22 (6%) men had a cardiac event (6 fatal) during follow up. Compared to patients who did not experience CAD event, subjects who developed a cardiac event were older (P = 0.008) and more frequently had hypertension (P = 0.01) and TD (48% vs 22%, P < 0.001). The prevalence of diabetes, hypercholesterolemia and smoking was not different between groups. Figure shows the adjusted Cox proportional hazard regression model for CAD events among TD patients and subjects with TT above the cut-off point. There was a significantly higher rate of CAD events in TD compared to patients with normal TT concentration [1.35 (95% CI, 1.10-1.62; P = 0.028) ] during study follow-up.

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