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F. Zu'bi, Y. Ofer, D. Amnipor, I. Gruenwald, S. Kol, G. Amiel, R. Tal, P-01-069 Sperm Cryopreservation and Utilization in Men with Testicular Cancer, The Journal of Sexual Medicine, Volume 13, Issue Supplement_2, May 2016, Page S166, https://doi.org/10.1016/j.jsxm.2016.03.220
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Objective
Testicular cancer is the most common malignancy in ages 20-40 years. Testicular cancer treatments have significant adverse effects on male fertility. Therefore, sperm cryopreservation before treatment is recommended. The aim of the study is to present the extent of semen cryopreservation, sperm parameters and sperm utilization in men with testicular cancer.
Methods
A review of patients’ charts and our institutional sperm bank data. Identification of men who had radical orchiectomy for testicular cancer in the years 2004-2014. Collection of demographic data, oncological data, sperm quality data and sperm utilization data.
Results
68 orchiectomy procedures were identified. Age was 30.9 ± 9.0 years (mean ± SD). 49% of men were single, 59% had no children and 17.5% had only 1 child. In 62% the tumor was localized to the testis. 54% had seminoma and 46% had non-seminoma germ cell tumor (NSGCT). Men with NSGCT were younger than men with seminoma (mean age 28.2years vs 35.2, p = 0.002). Sperm cryopreservation was done in 87.7%. Sperm concentration was above the lower threshold (WHO 2010 criteria) in 53.1% and motility was normal in 59.4%. In 9.2% only few sperm cells were found and 12.3% had azoospermia. Seminoma cases had higher sperm concentration (59.2mii/ml vs 30.2, p = 0.015) and better motility (56.9% vs 47.6, p = 0.013) than NSGCT. With disseminated tumors, there was a trend of worse sperm quality. Followup was 66 ± 35.5months (mean ± SD). Only 16% of men used the cryopreserved sperm. Median time to sperm utilization was 5 years. 10% requested to discontinue preservation and for 74% the sperm is still cryopreserved. In 12%, it was impossible to contact the patients. Age and marital status were not predictive of sperm utilization. A trend of higher sperm utilization was observed in men with NSGCT and in men with no children or with a single child.
