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Sarah Wåhlin‐Jacobsen, Anette Tønnes Pedersen, Ellid Kristensen, Nanna Cassandra Læssøe, Marika Lundquist, Arieh S. Cohen, David M. Hougaard, Annamaria Giraldi, Response to Comment on “Is There a Correlation Between Androgens and Sexual Desire in Women?”, The Journal of Sexual Medicine, Volume 12, Issue 8, August 2015, Pages 1851–1852, https://doi.org/10.1111/jsm.12945
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We are grateful for the interest of estimated researchers [1] in our paper [2], especially as our study have been inspired by their scientific publications. However, we kindly disagree in some of the comments.
The present study has a consistent hypothesis that androgens are involved in female sexual function, as one of the bio‐psycho‐social factors affecting women's sexuality. The inconsistency in previous findings may be explained by insensitive steroid assays and/or intracrinology. It is claimed that our conclusion “presupposes an established correlation between androgens and sexual desire.” No assumption was made. The correlation is clearly demonstrated and discussed in our paper. The fact that both our and a previous study [3] do not find any statistically significant correlations between androsterone glucuronide (ADT‐G) and female sexual function does not negate the relevance of intracellular androgen turnover in women.
The choice of ADT‐G as a biomarker of androgenic activity was based on previous findings, where ADT‐G is proposed to represent 93% of the degradation products from the intracellular androgen turnover [4]. However, ADT‐G is primarily indicative of adrenal preandrogen secretion [5], and a more complex mechanism might be involved. Our endpoints were based on the existing knowledge and research on the subject at the time being.
