... investigated as interictal biomarkers of epilepsy. Yet, their value is largely debated due to the presence of physiological oscillations, which complicate distinguishing between normal versus abnormal events. So far, this debate has been addressed using intracranial EEG data from patients with drug-resistant...

... epilepsy mouse model ECoG drug response ACCEPTED MANUSCRIPT 1 A mouse model of GRIN2D developmental and epileptic 2 encephalopathy recapitulates the human disease 3 Mor Yam,1, Jolan Nassir,1, Danielle Galber,2,3 Shir Quinn,1 Roni Gal,1,3 Mor Ovadia,3 Mor 4 Bordeynik-Cohen,2 Eden Peled,2 Christopher D...

... and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Post-stroke seizures and epilepsy can affect patients' quality of life, increase mortality in stroke patients, affect...

... matrix FDA: Food & Drug Administration GABA: -aminobutyric acid GABAAR: GABAA receptor GABRA1: GABAAR- 1 GluCEST: glutamate-weighted chemical exchange saturation transfer GNT: glioneuronal tumor Accepted Manuscript GPC3: glypican 3 GRE: glioma-related epilepsy HGG: high-grade glioma IDH: isocitrate...

.... Correspondence to: Petr Nejedly Faculty of Medicine, Masaryk University Kamenice 5, Brno 625 00, Czech Republic E-mail: [email protected] The inclusion criteria were met by 80 patients (34 females, 46 males, mean age 33 ± 10 years) diagnosed with DRE indicated for epilepsy surgery (n = 57, 24 Engel...

.... Teoh et al. generate a mouse model with the V664I variant, similar to one found in human patients, and show that a proof-of-concept precision therapeutic intervention reduces seizure burden in the model. GRIN2D epilepsy synaptic dysfunction neurodevelopment seizures 1...

... This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Temporal lobe epilepsy...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Data are emerging on beneficial effects of KD in some neurometabolic disorders in which epilepsy is common. ⁵ These include glucose transporter...

... disorders caused by de novo variants that disturb the synaptic release machinery. These neurodevelopmental disorders comprise highly diverse clinical phenotypes, usually including developmental delay, epilepsy, intellectual disability, and sometimes autism spectrum disorder. Despite major progress...

... currents bidirectionally modulates spatiotemporal SD susceptibility. Aiba et al. reveal bilateral waves of cortical spreading depolarization in a mouse model carrying a sodium ion channel mutation identified in patients with severe epilepsy. Targeting persistently open ion channels using...

... interictal spike co-activation, seizure localization and resting-state EEG activity in children with medically refractory epilepsy. Twenty paediatric patients (mean age: 10.6 years) undergoing invasive EEG investigation with subdural electrodes were examined. Automated techniques were used to extract time...

... of medicine 17.87 ± 17.68 ^a ND ND ND Dose of medicine 0.78 ± 0.78 ^a ND ND ND Seizure frequency (per month) 5.29 ± 8.66 ^a ND ND ND Note: Values are mean ± standard deviation (SD). Abbreviations: SeLECTS, Self-limited epilepsy with Centrotemporal Spikes...

... with epilepsy. Prescribing errors for these patients can result in inadvertent carbohydrate exposure, increasing the risk of loss of ketosis and breakthrough seizures. The objective of this study was to evaluate the incidence of inadvertent carbohydrate exposure in hospitalized children on the traditional KD...

... the modulatory effect of extreme capsule stimulation on the cortex in patients with drug-resistant epilepsy. Their findings highlight the therapeutic potential of this approach for seizures originating in physically connected cortex and provide new insights into the theoretical framework of neuromodulation...

... Disabilities Research Center 10.13039/100007857 National Institute of Child Health and Human Development 10.13039/100000071 P30 HD018655 Focal epilepsies, especially associated with malformations of cortical development (MCDs), are an important cause of paediatric drug-resistant epilepsy (DRE...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. blood-based biomarkers brain injury drug-resistant epilepsy neurodegeneration Jeansson Foundations 10.13039/100008738 Swedish Society for Medical...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Epilepsy is recognized as one of the leading targets for precision medicine, following on from the successes in cancer therapy, due to its substantial...

... Street London WC1N 1EH, UK E-mail: [email protected] Epilepsy is the most common neurological condition in childhood, with a cumulative incidence of 0.66% at 10 years of age. ¹...

.... Abstract Alzheimer's disease increases the risk of developing epilepsy together with cognitive decline. Early diagnosis or prediction of parameters associated with epileptic activity can greatly help in managing disease outcomes. Network hyperexcitability is a candidate of interest as a neurophysiological...

... for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Epilepsy is one of the most common neurological disorders. Neuroinflammation...